Is Betaxolol Safe in Breastfeeding

I am a breastfeeding mother and i want to know if it is safe to use Betaxolol? Is Betaxolol safe for nursing mother and child? Does Betaxolol extracts into breast milk? Does Betaxolol has any long term or short term side effects on infants? Can Betaxolol influence milk supply or can Betaxolol decrease milk supply in lactating mothers?

Because of its relatively extensive excretion into breastmilk and minimal reported experience during breastfeeding, other beta-blocking agents may be preferred for systemic use, especially while nursing a newborn or preterm infant. With use of betaxolol eye drops, it is not likely that sufficient amounts would be present in milk to affect the infant. To substantially diminish the amount of drug that reaches the breastmilk after using eye drops, place pressure over the tear duct by the corner of the eye for 1 minute or more, then remove the excess solution with an absorbent tissue.

A study of mothers taking beta-blockers during nursing found a numerically, but not statistically significant increased number of adverse reactions in those taking any beta-blocker. Although the ages of infants were matched to control infants, the ages of the affected infants were not stated. None of the mothers were taking betaxolol.[3] Beta-adrenergic blocking drugs with breastmilk excretion characteristics similar to betaxolol have caused adverse effects in breastfed newborns.[4][5]

Relevant published information on the effects of beta-blockade or betaxolol during normal lactation was not found as of the revision date. A study in 6 patients with hyperprolactinemia and galactorrhea found no changes in serum prolactin levels following beta-adrenergic blockade with propranolol.[6]