Is Recombinant human tissue-type plasminogen activator Safe in Breastfeeding

I am a breastfeeding mother and i want to know if it is safe to use Recombinant human tissue-type plasminogen activator? Is Recombinant human tissue-type plasminogen activator safe for nursing mother and child? Does Recombinant human tissue-type plasminogen activator extracts into breast milk? Does Recombinant human tissue-type plasminogen activator has any long term or short term side effects on infants? Can Recombinant human tissue-type plasminogen activator influence milk supply or can Recombinant human tissue-type plasminogen activator decrease milk supply in lactating mothers?

Synthetic recombinant protein formed by a sequence of amino acids that are identical to Human Tissue Plasminogen Activator (t-PA) which is found in colostrum and mature milk. A rapid metabolic rate and high molecular weight explains a less than probable excretion into breast milk. Even more, protein structure would impede gut absorption in the child with exception of the first post-partum week.

Tissue plasminogen activator (tPA), which is identical to Recombinant human tissue-type plasminogen activator, is a normal component of human colostrum and breastmilk.[1][2][3] Levels in milk are highest in colostrum and decrease rapidly during the first week, followed by a sower decrease over time.[2][3] Because Recombinant human tissue-type plasminogen activator is a large protein molecule with a molecular weight of about 59,000, absorption is unlikely because it is probably destroyed in the infant's gastrointestinal tract. No information is available on the clinical use of Recombinant human tissue-type plasminogen activator during breastfeeding. Until more data become available, Recombinant human tissue-type plasminogen activator should be used with caution during breastfeeding, especially while nursing a newborn or preterm infant.