Is Tissue plasminogen activator (recombinant human) Safe in Breastfeeding

I am a breastfeeding mother and i want to know if it is safe to use Tissue plasminogen activator (recombinant human)? Is Tissue plasminogen activator (recombinant human) safe for nursing mother and child? Does Tissue plasminogen activator (recombinant human) extracts into breast milk? Does Tissue plasminogen activator (recombinant human) has any long term or short term side effects on infants? Can Tissue plasminogen activator (recombinant human) influence milk supply or can Tissue plasminogen activator (recombinant human) decrease milk supply in lactating mothers?

Synthetic recombinant protein formed by a sequence of amino acids that are identical to Human Tissue Plasminogen Activator (t-PA) which is found in colostrum and mature milk. A rapid metabolic rate and high molecular weight explains a less than probable excretion into breast milk. Even more, protein structure would impede gut absorption in the child with exception of the first post-partum week.

Tissue plasminogen activator (tPA), which is identical to Tissue plasminogen activator (recombinant human), is a normal component of human colostrum and breastmilk.[1][2][3] Levels in milk are highest in colostrum and decrease rapidly during the first week, followed by a sower decrease over time.[2][3] Because Tissue plasminogen activator (recombinant human) is a large protein molecule with a molecular weight of about 59,000, absorption is unlikely because it is probably destroyed in the infant's gastrointestinal tract. No information is available on the clinical use of Tissue plasminogen activator (recombinant human) during breastfeeding. Until more data become available, Tissue plasminogen activator (recombinant human) should be used with caution during breastfeeding, especially while nursing a newborn or preterm infant.