Is rtPA Safe in Breastfeeding

I am a breastfeeding mother and i want to know if it is safe to use rtPA? Is rtPA safe for nursing mother and child? Does rtPA extracts into breast milk? Does rtPA has any long term or short term side effects on infants? Can rtPA influence milk supply or can rtPA decrease milk supply in lactating mothers?

Synthetic recombinant protein formed by a sequence of amino acids that are identical to Human Tissue Plasminogen Activator (t-PA) which is found in colostrum and mature milk. A rapid metabolic rate and high molecular weight explains a less than probable excretion into breast milk. Even more, protein structure would impede gut absorption in the child with exception of the first post-partum week.

Tissue plasminogen activator (tPA), which is identical to rtPA, is a normal component of human colostrum and breastmilk.[1][2][3] Levels in milk are highest in colostrum and decrease rapidly during the first week, followed by a sower decrease over time.[2][3] Because rtPA is a large protein molecule with a molecular weight of about 59,000, absorption is unlikely because it is probably destroyed in the infant's gastrointestinal tract. No information is available on the clinical use of rtPA during breastfeeding. Until more data become available, rtPA should be used with caution during breastfeeding, especially while nursing a newborn or preterm infant.