Question

I am a breastfeeding mother and i want to know if it is safe to use Amidine Hydrochloride? Is Amidine Hydrochloride safe for nursing mother and child? Does Amidine Hydrochloride extracts into breast milk? Does Amidine Hydrochloride has any long term or short term side effects on infants? Can Amidine Hydrochloride influence milk supply or can Amidine Hydrochloride decrease milk supply in lactating mothers?

Amidine Hydrochloride lactation summary

Amidine Hydrochloride is safe in breastfeeding
  • DrLact safety Score for Amidine Hydrochloride is 1 out of 8 which is considered Safe as per our analyses.
  • A safety Score of 1 indicates that usage of Amidine Hydrochloride is mostly safe during lactation for breastfed baby.
  • Our study of different scientific research also indicates that Amidine Hydrochloride does not cause any serious side effects in breastfeeding mothers.
  • Most of scientific studies and research papers declaring usage of Amidine Hydrochloride safe in breastfeeding are based on normal dosage and may not hold true for higher dosage.
  • Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.

Answer by Dr. Ru: About Amidine Hydrochloride usage in lactation

Drugs used in the treatment of opioid dependence and treatment of neonatal opiate withdrawal. It is excreted in breast milk in clinically non-significant amount without problems in the short or long term in infants whose mothers were treated. Plasma levels of these infants were undetectable or very low. The dose that gets the infant through the mother's milk, even when taking 70-150 mg a-day, is much lower than that used to treat neonatal abstinence syndrome. This is a reason for not using it as a solely measure of treatment. It should be reinforced that it is observed a non-polydrug behavior and adequacy of maternal care is maintained. Many newborns are either premature or underweight infants, and over 60% develop withdrawal syndrome at about one post-natal month. Breastfeeding with regard to the entire context of addictive behavior is neither easy nor frequently achieved. Much help is needed on supporting addicted mothers by health and social services in the community. Methadone excretion into breast milk is minimal regardless of the dose taken by the mother. No correlation was found between maternal dose and concentration in either breast milk or infant plasma.It has been shown delayed onset of neonatal abstinence syndrome, less need for drug treatment and lower average of hospital stay in breastfed infants.High doses can lead to a slow start (within 2-6 weeks) of withdrawal syndrome when breastfeeding is suddenly stopped. Methadone can cause galactorrhea due to increased prolactin secretion.
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