Is 40-O-(2-hydroxyethyl)-rapamycin Safe in Breastfeeding

I am a breastfeeding mother and i want to know if it is safe to use 40-O-(2-hydroxyethyl)-rapamycin? Is 40-O-(2-hydroxyethyl)-rapamycin safe for nursing mother and child? Does 40-O-(2-hydroxyethyl)-rapamycin extracts into breast milk? Does 40-O-(2-hydroxyethyl)-rapamycin has any long term or short term side effects on infants? Can 40-O-(2-hydroxyethyl)-rapamycin influence milk supply or can 40-O-(2-hydroxyethyl)-rapamycin decrease milk supply in lactating mothers?

• DrLact safety Score for 40-O-(2-hydroxyethyl)-rapamycin is 5 out of 8 which is considered Unsafe as per our analyses.
• A safety Score of 5 indicates that usage of 40-O-(2-hydroxyethyl)-rapamycin may cause serious side effects in breastfed baby.
• Our study of different scientific research indicates that 40-O-(2-hydroxyethyl)-rapamycin may cause moderate to high side effects or may affect milk supply in lactating mother.
• Our suggestion is to use safer alternate options rather than using 40-O-(2-hydroxyethyl)-rapamycin .
• It is recommended to evaluate the advantage of not breastfeeding while using 40-O-(2-hydroxyethyl)-rapamycin Vs not using 40-O-(2-hydroxyethyl)-rapamycin And continue breastfeeding.
• While using 40-O-(2-hydroxyethyl)-rapamycin Its must to monitor child for possible reactions. It is also important to understand that side effects vary largely based on age of breastfed child and time of medication in addition to dosage.
• Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.

On latest update relevant data on breastfeeding was not found. Pharmacokinetic data (high molecular weight but low protein binding) indicates that drug excretion into breast milk would be moderately high. Low oral biodisponibility would be protective for breastfed children who are not newborn or premature. Until new data is available nursing should be delayed for a 5-half lives period (150 hours - 6 to 7 days) after last intake.

In one patient, 40-O-(2-hydroxyethyl)-rapamycin was not detected in the colostrum of a mother taking 40-O-(2-hydroxyethyl)-rapamycin; however, no information is available on the use of 40-O-(2-hydroxyethyl)-rapamycin during breastfeeding. An alternate drug may be preferred, especially while nursing a newborn or preterm infant.