Is 7-Chloro-5-(2-chlorophenyl)-3-hydroxy-1-methyl-2,3-dihydro-1H-1,4-benzodiazepin-2-one Safe in Breastfeeding

I am a breastfeeding mother and i want to know if it is safe to use 7-Chloro-5-(2-chlorophenyl)-3-hydroxy-1-methyl-2,3-dihydro-1H-1,4-benzodiazepin-2-one? Is 7-Chloro-5-(2-chlorophenyl)-3-hydroxy-1-methyl-2,3-dihydro-1H-1,4-benzodiazepin-2-one safe for nursing mother and child? Does 7-Chloro-5-(2-chlorophenyl)-3-hydroxy-1-methyl-2,3-dihydro-1H-1,4-benzodiazepin-2-one extracts into breast milk? Does 7-Chloro-5-(2-chlorophenyl)-3-hydroxy-1-methyl-2,3-dihydro-1H-1,4-benzodiazepin-2-one has any long term or short term side effects on infants? Can 7-Chloro-5-(2-chlorophenyl)-3-hydroxy-1-methyl-2,3-dihydro-1H-1,4-benzodiazepin-2-one influence milk supply or can 7-Chloro-5-(2-chlorophenyl)-3-hydroxy-1-methyl-2,3-dihydro-1H-1,4-benzodiazepin-2-one decrease milk supply in lactating mothers?

Benzodiazepine of short-term action. It is excreted into breastmilk in clinically non-significant amount without problems been observed in infants from treated mothers (Humpel 1982, Lemmer 2007). Drug plasma levels in these infants were undetectable or either very low (Humpel 1982). Infrequent use and a low dose of benzodiazepines is compatible with breastfeeding. Short-acting Benzodiazepines should be chosen along with a minimum effective dose as possible, especially in the neonatal period. Assess for drowsiness and inappropriate infant feeding pattern. It is not recommended bed-sharing with your baby if you are on this medication.

7-Chloro-5-(2-chlorophenyl)-3-hydroxy-1-methyl-2,3-dihydro-1H-1,4-benzodiazepin-2-one is not approved for marketing in the United States by the U.S. Food and Drug Administration. 7-Chloro-5-(2-chlorophenyl)-3-hydroxy-1-methyl-2,3-dihydro-1H-1,4-benzodiazepin-2-one has low levels in breastmilk and a short half-life relative to many other benzodiazepines. Limited evidence from nursing mothers indicates that lorazepam does not cause any adverse effects in breastfed infants with usual maternal dosages. No special precautions are required.

Five women who were 2 to 3 days postpartum took 2 mg of 7-Chloro-5-(2-chlorophenyl)-3-hydroxy-1-methyl-2,3-dihydro-1H-1,4-benzodiazepin-2-one daily at 8 pm for 10 days and fully breastfed their infants. The authors of the study noted no pharmacological or adverse effects in any of the infants during the study.[1]