Question

I am a breastfeeding mother and i want to know if it is safe to use Granulocyte colony-stimulating factor (G-CSF)? Is Granulocyte colony-stimulating factor (G-CSF) safe for nursing mother and child? Does Granulocyte colony-stimulating factor (G-CSF) extracts into breast milk? Does Granulocyte colony-stimulating factor (G-CSF) has any long term or short term side effects on infants? Can Granulocyte colony-stimulating factor (G-CSF) influence milk supply or can Granulocyte colony-stimulating factor (G-CSF) decrease milk supply in lactating mothers?

Granulocyte colony-stimulating factor (G-CSF) lactation summary

Granulocyte colony-stimulating factor (G-CSF) is safe in breastfeeding
  • DrLact safety Score for Granulocyte colony-stimulating factor (G-CSF) is 1 out of 8 which is considered Safe as per our analyses.
  • A safety Score of 1 indicates that usage of Granulocyte colony-stimulating factor (G-CSF) is mostly safe during lactation for breastfed baby.
  • Our study of different scientific research also indicates that Granulocyte colony-stimulating factor (G-CSF) does not cause any serious side effects in breastfeeding mothers.
  • Most of scientific studies and research papers declaring usage of Granulocyte colony-stimulating factor (G-CSF) safe in breastfeeding are based on normal dosage and may not hold true for higher dosage.
  • Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.

Answer by Dr. Ru: About Granulocyte colony-stimulating factor (G-CSF) usage in lactation

Non-glycosylated stimulating factor of granulocyte colonies (G-CSF) which is obtained by recombinant technology.The naturally occurring product is found in breast milk. A very high molecular weight explains the insignificant or no excretion into milk that has been observed both with Lenograstim and Filgrastim. Its low oral bioavailability hampers absorption into infant plasma from the breast milk ingested, as for their proteic nature it is degraded in the gastrointestinal tract, not being absorbed. Filgrastim is not absorbed by the infant's gut even during the neonatal period or prematurity. The granulocyte colony-stimulating factor has been used in premature newborns, both on prevention and treatment of neonatal sepsis and/or necrotizing enterocolitis without adverse effects being observed among treated infants. The bovine G-CSF is found in the usual diet of meat eaters.
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