Is UNII-GU56C842ZA Safe in Breastfeeding
Question
I am a breastfeeding mother and i want to know if it is safe to use UNII-GU56C842ZA? Is UNII-GU56C842ZA safe for nursing mother and child? Does UNII-GU56C842ZA extracts into breast milk? Does UNII-GU56C842ZA has any long term or short term side effects on infants? Can UNII-GU56C842ZA influence milk supply or can UNII-GU56C842ZA decrease milk supply in lactating mothers?
UNII-GU56C842ZA lactation summary
- DrLact safety Score for UNII-GU56C842ZA is 1 out of 8 which is considered Safe as per our analyses.
- A safety Score of 1 indicates that usage of UNII-GU56C842ZA is mostly safe during lactation for breastfed baby.
- Our study of different scientific research also indicates that UNII-GU56C842ZA does not cause any serious side effects in breastfeeding mothers.
- Most of scientific studies and research papers declaring usage of UNII-GU56C842ZA safe in breastfeeding are based on normal dosage and may not hold true for higher dosage.
- Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.
Answer by Dr. Ru: About UNII-GU56C842ZA usage in lactation
Benzodiazepine of short-term action. It is excreted into breastmilk in clinically non-significant amount without problems been observed in infants from treated mothers (Humpel 1982, Lemmer 2007). Drug plasma levels in these infants were undetectable or either very low (Humpel 1982). Infrequent use and a low dose of benzodiazepines is compatible with breastfeeding. Short-acting Benzodiazepines should be chosen along with a minimum effective dose as possible, especially in the neonatal period. Assess for drowsiness and inappropriate infant feeding pattern. It is not recommended bed-sharing with your baby if you are on this medication.
Answer by DrLact: About UNII-GU56C842ZA usage in lactation
UNII-GU56C842ZA is not approved for marketing in the United States by the U.S. Food and Drug Administration. UNII-GU56C842ZA has low levels in breastmilk and a short half-life relative to many other benzodiazepines. Limited evidence from nursing mothers indicates that lorazepam does not cause any adverse effects in breastfed infants with usual maternal dosages. No special precautions are required.
UNII-GU56C842ZA Side Effects in Breastfeeding
Five women who were 2 to 3 days postpartum took 2 mg of UNII-GU56C842ZA daily at 8 pm for 10 days and fully breastfed their infants. The authors of the study noted no pharmacological or adverse effects in any of the infants during the study.[1]
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