Question

I am a breastfeeding mother and i want to know if it is safe to use 5-23-04-00478 (Beilstein Handbook Reference)? Is 5-23-04-00478 (Beilstein Handbook Reference) safe for nursing mother and child? Does 5-23-04-00478 (Beilstein Handbook Reference) extracts into breast milk? Does 5-23-04-00478 (Beilstein Handbook Reference) has any long term or short term side effects on infants? Can 5-23-04-00478 (Beilstein Handbook Reference) influence milk supply or can 5-23-04-00478 (Beilstein Handbook Reference) decrease milk supply in lactating mothers?

5-23-04-00478 (Beilstein Handbook Reference) lactation summary

5-23-04-00478 (Beilstein Handbook Reference) is safe in breastfeeding
  • DrLact safety Score for 5-23-04-00478 (Beilstein Handbook Reference) is 1 out of 8 which is considered Safe as per our analyses.
  • A safety Score of 1 indicates that usage of 5-23-04-00478 (Beilstein Handbook Reference) is mostly safe during lactation for breastfed baby.
  • Our study of different scientific research also indicates that 5-23-04-00478 (Beilstein Handbook Reference) does not cause any serious side effects in breastfeeding mothers.
  • Most of scientific studies and research papers declaring usage of 5-23-04-00478 (Beilstein Handbook Reference) safe in breastfeeding are based on normal dosage and may not hold true for higher dosage.
  • Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.

Answer by Dr. Ru: About 5-23-04-00478 (Beilstein Handbook Reference) usage in lactation

Antiprotozoan drug used for the treatment of American Trypanosomiasis (Trypanosoma cruzi) or Chagas Disease (see specific info). It is excreted into breast milk in small amounts and there have not been observed problems in infants from treated mothers (Garcia-Bournissen 2015, Vela-Bahena 2015). 5-23-04-00478 (Beilstein Handbook Reference) has been very well tolerated when administered directly to infants and newborns (Altcheh 2011, Chippaux 2013).

Answer by DrLact: About 5-23-04-00478 (Beilstein Handbook Reference) usage in lactation

5-23-04-00478 (Beilstein Handbook Reference) is excreted into milk in dosages much lower than the treatment dosage for infants. Because of the low levels of 5-23-04-00478 (Beilstein Handbook Reference) in breastmilk and safety when given directly to infants, its use is acceptable in nursing mothers.

5-23-04-00478 (Beilstein Handbook Reference) Side Effects in Breastfeeding

Ten women with chronic Chagas disease received 5-23-04-00478 (Beilstein Handbook Reference) in a median oral dose of 5.65 mg/kg twice daily for 30 days. Median infant age Ten women with chronic Chagas disease received 5-23-04-00478 (Beilstein Handbook Reference) in a median oral dose of 5.65 mg/kg twice daily for 30 days. Median infant age was 5.2 months (range 20 days-13 months). Five children were exclusively breastfed and the others partially breastfed. None of the infants had any adverse reactions attributable to 5-23-04-00478 (Beilstein Handbook Reference).[4] A postpartum woman diagnosed with Chagas disease was treated with 5-23-04-00478 (Beilstein Handbook Reference) 5 mg/kg daily beginning one month postpartum and continuing for 30 days. She continued to breastfeed (extent not stated) her infant. The authors reported that no adverse effects were seen in the infant.[6]
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