Question

I am a breastfeeding mother and i want to know if it is safe to use UNII-YC42NRJ1ZD? Is UNII-YC42NRJ1ZD safe for nursing mother and child? Does UNII-YC42NRJ1ZD extracts into breast milk? Does UNII-YC42NRJ1ZD has any long term or short term side effects on infants? Can UNII-YC42NRJ1ZD influence milk supply or can UNII-YC42NRJ1ZD decrease milk supply in lactating mothers?

UNII-YC42NRJ1ZD lactation summary

UNII-YC42NRJ1ZD is safe in breastfeeding
  • DrLact safety Score for UNII-YC42NRJ1ZD is 1 out of 8 which is considered Safe as per our analyses.
  • A safety Score of 1 indicates that usage of UNII-YC42NRJ1ZD is mostly safe during lactation for breastfed baby.
  • Our study of different scientific research also indicates that UNII-YC42NRJ1ZD does not cause any serious side effects in breastfeeding mothers.
  • Most of scientific studies and research papers declaring usage of UNII-YC42NRJ1ZD safe in breastfeeding are based on normal dosage and may not hold true for higher dosage.
  • Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.

Answer by Dr. Ru: About UNII-YC42NRJ1ZD usage in lactation

Antiprotozoan drug used for the treatment of American Trypanosomiasis (Trypanosoma cruzi) or Chagas Disease (see specific info). It is excreted into breast milk in small amounts and there have not been observed problems in infants from treated mothers (Garcia-Bournissen 2015, Vela-Bahena 2015). UNII-YC42NRJ1ZD has been very well tolerated when administered directly to infants and newborns (Altcheh 2011, Chippaux 2013).

Answer by DrLact: About UNII-YC42NRJ1ZD usage in lactation

UNII-YC42NRJ1ZD is excreted into milk in dosages much lower than the treatment dosage for infants. Because of the low levels of UNII-YC42NRJ1ZD in breastmilk and safety when given directly to infants, its use is acceptable in nursing mothers.

UNII-YC42NRJ1ZD Side Effects in Breastfeeding

Ten women with chronic Chagas disease received UNII-YC42NRJ1ZD in a median oral dose of 5.65 mg/kg twice daily for 30 days. Median infant age Ten women with chronic Chagas disease received UNII-YC42NRJ1ZD in a median oral dose of 5.65 mg/kg twice daily for 30 days. Median infant age was 5.2 months (range 20 days-13 months). Five children were exclusively breastfed and the others partially breastfed. None of the infants had any adverse reactions attributable to UNII-YC42NRJ1ZD.[4] A postpartum woman diagnosed with Chagas disease was treated with UNII-YC42NRJ1ZD 5 mg/kg daily beginning one month postpartum and continuing for 30 days. She continued to breastfeed (extent not stated) her infant. The authors reported that no adverse effects were seen in the infant.[6]
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