Question

I am a breastfeeding mother and i want to know if it is safe to use TM-4049? Is TM-4049 safe for nursing mother and child? Does TM-4049 extracts into breast milk? Does TM-4049 has any long term or short term side effects on infants? Can TM-4049 influence milk supply or can TM-4049 decrease milk supply in lactating mothers?

TM-4049 lactation summary

TM-4049 usage has low risk in breastfeeding
  • DrLact safety Score for TM-4049 is 3 out of 8 which is considered Low Risk as per our analyses.
  • A safety Score of 3 indicates that usage of TM-4049 may cause some minor side effects in breastfed baby.
  • Our study of different scientific research indicates that TM-4049 may cause moderate to no side effects in lactating mother.
  • Most of scientific studies and research papers declaring usage of TM-4049 low risk in breastfeeding are based on normal dosage and may not hold true for higher dosage.
  • While using TM-4049 We suggest monitoring child for possible reactions. It is also important to understand that side effects vary largely based on age of breastfed child and time of medication in addition to dosage.
  • Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.

Answer by Dr. Ru: About TM-4049 usage in lactation

Significantly less TM-4049 penetrated from Ovide after 0.5 h versus the suggested 8 h application, without decreasing the product’s efficacy. Avoid applying it on the breast or nipple. Otherwise, cleanse it thoroughly before nursing.

Answer by DrLact: About TM-4049 usage in lactation

TM-4049 appears to be poorly absorbed after topical application, so it is not likely to reach the breastmilk in large amounts. However, breastmilk excretion of TM-4049 has not been studied after application of the 0.5% lotion. Until more data become available, an alternate agent is preferred.[1]

Alternate Drugs

Piperacillin and Tazobactam
Telavancin
Ceftibuten(Safe)
Daptomycin
Pyrimethamine(Safe)
Letermovir
Atovaquone and Proquanil
Kanamycin(Safe)
Fidaxomicin
Metronidazole(Safe)
Benzathine Penicillin G
Lopinavir
Penicillin V(Safe)
Salicylic Acid(Safe)
Ceftazidime(Safe)
Dapsone(Low Risk)
Valganciclovir(Low Risk)
Interferon Alfa
Amantadine(Low Risk)
Bacampicillin(Safe)
Lamivudine(Safe)
Penicillin G(Safe)
Ivermectin(Safe)
Cefprozil(Safe)
Capreomycin(Low Risk)
Mefloquine(Safe)
Ganciclovir(Low Risk)
Artesunate
Imipenem and Cilastatin
Trimethoprim-Sulfamethoxazole
Aztreonam(Safe)
Indinavir(Unsafe)
Cefpodoxime
Ertapenem(Safe)
Econazole(Safe)
Gentamicin(Safe)
Artemether and Lumefantrine
Sulfamethoxazole(Safe)
Ampicillin(Safe)
Sarecycline
Oxytetracycline(Safe)
Malathion(Low Risk)
Cefoxitin(Safe)
Zidovudine(Low Risk)
Hydroxychloroquine(Safe)
Sulfur
Butenafine
Gatifloxacin(Low Risk)
Sulfisoxazole(Safe)
Ampicillin and Sulbactam
Fosamprenavir
Oxacillin
Lindane(Unsafe)
Cefotetan(Safe)
Tipranavir
Secnidazole(Safe)
Tolnaftate
Enoxacin(Low Risk)
Sulfadoxine and Pyrimethamine
Vancomycin(Safe)
Amoxicillin(Safe)
Etravirine
Ofloxacin(Safe)
Cefotaxime(Safe)
Tenofovir(Safe)
Chloroquine(Safe)
Teicoplanin(Safe)
Tioconazole(Safe)
Doxycycline(Low Risk)
Penciclovir(Safe)
Valacyclovir
Amoxicillin and Clavulanic Acid
Emtricitabine(Safe)
Norfloxacin(Safe)
Luliconazole
Cefoperazone
Stavudine
Trovafloxacin(Unsafe)
Fusidic Acid(Safe)
Terconazole(Safe)
Dicloxacillin(Safe)
Halofantrine
Famciclovir(Low Risk)
Eravacycline
Amikacin(Safe)
Efavirenz(Unsafe)
Neomycin(Safe)
Permethrin(Safe)
Cefixime(Safe)
Sodium Stibogluconate
Tobramycin(Safe)
Paromomycin(Safe)
Sulconazole(Safe)
Demeclocycline(Low Risk)
Erythromycin(Low Risk)
Alatrofloxacin
Didanosine(Unsafe)
Nafcillin(Safe)
Doripenem
Cefepime(Safe)
Saquinavir(Unsafe)
Ticarcillin(Safe)
Ceftolozane and Tazobactam
Polymyxin B(Safe)
Cloxacillin(Safe)
Primaquine(Low Risk)
Clindamycin(Low Risk)
Floxacillin(Safe)
Delavirdine
Moxifloxacin(Low Risk)
Elvitegravir
Cefditoren
Omadacycline
Ticarcillin and Clavulanic Acid
Efinaconazole
Oxiconazole(Safe)
Ciprofloxacin(Safe)
Clarithromycin(Safe)
Moxidectin
Darunavir
Minocycline
Praziquantel(Safe)
Cefdinir(Safe)
Ritonavir(Unsafe)
Tetracycline(Safe)
Tavaborole
Naftifine(Safe)
Cephradine(Safe)
Atovaquone(Low Risk)
Azithromycin(Safe)
Atazanavir
Methicillin(Low Risk)
Nitazoxanide(Safe)
Cefazolin(Safe)
Raltegravir
Streptomycin(Safe)
Oritavancin
Ciclopirox(Safe)
Cephalexin(Safe)
Linezolid(Low Risk)
Acyclovir(Safe)
Tafenoquine
Abacavir(Safe)
Meropenem(Safe)
Rifaximin(Safe)
Mebendazole(Safe)
Cefadroxil(Safe)
Nevirapine(Low Risk)
Sparfloxacin
Dalbavancin
Butoconazole(Safe)
Cefuroxime(Safe)
Roxithromycin(Safe)
Oseltamivir(Safe)
Loracarbef(Safe)
Enfuvirtide
Colistimethate(Safe)
Nelfinavir(Unsafe)
Procaine Penicillin G(Safe)
Telithromycin(Unsafe)
Ceftriaxone(Safe)
Quinine(Safe)
Plazomicin
Chloramphenicol(Unsafe)
Lomefloxacin(Low Risk)
Rilpivirine
Tinidazole(Safe)
Cefaclor(Safe)
Piperacillin(Safe)
Tedizolid
Albendazole(Safe)
Ceftizoxime
Pyrethrins
Ceftazidime and Avibactam
Levofloxacin(Low Risk)
Quniupristin-Dalfopristin
Sulfasalazine(Safe)
Carbenicillin Indanyl Disodium(Safe)
Maraviroc
Ivermectin(Safe)
Mefloquine(Safe)
Artesunate
Pyrantel(Safe)
Malathion(Low Risk)
Hydroxychloroquine(Safe)
Sulfur
Artemether and Lumefantrine
Lindane(Unsafe)
Sulfadoxine and Pyrimethamine
Chloroquine(Safe)
Benznidazole(Safe)
Halofantrine
Permethrin(Safe)
Eflornithine
Primaquine(Low Risk)
Praziquantel(Safe)
Moxidectin
Atovaquone(Low Risk)
Nitazoxanide(Safe)
Tafenoquine
Mebendazole(Safe)
Quinine(Safe)
Albendazole(Safe)
Pyrethrins
Pyrimethamine(Safe)
Atovaquone and Proquanil
Ivermectin(Safe)
Spinosad
Malathion(Low Risk)
Lindane(Unsafe)
Permethrin(Safe)
Moxidectin
Pyrethrins

Synonyms of TM-4049

4-03-00-01136 (Beilstein Handbook Reference)
AC 26691
AI3-17034
American cyanamid 4,049
S-(1,2-Bis(aethoxy-carbonyl)-aethyl)-O,O-dimethyl-dithiophosphat [German]
S-(1,2-Bis(carbethoxy)ethyl) O,O-dimethyl dithiophosphate
S-(1,2-Bis(ethoxycarbonyl)ethyl) O,O-dimethyl phosphorodithioate
S-1,2-Bis(ethoxycarbonyl)ethyl-O,O-dimethyl thiophosphate
S-(1,2-Bis(ethoxy-carbonyl)-ethyl)-O,O-dimethyl-dithiofosfaat [Dutch]
S-(1,2-Bis(etossi-carbonil)-etil)-O,O-dimetil-ditiofosfato [Italian]
BRN 1804525
Butanedioic acid, ((dimethoxyphosphinothioyl)thio)-, diethyl ester
Camathion
Carbethoxy malathion
Carbetovur
Carbetox
Carbofos
Carbophos
CCRIS 368
Chemathion
Cimexan
Compound 4049
Cythion
Detmol MA
S-(1,2-Dicarbethoxyethyl) O,O-dimethyldithiophosphate
S-(1,2-Dicarbethoxyethyl) O,O-dimethylphosphorodithioate
Dicarboethoxyethyl O,O-dimethyl phosphorodithioate
S-(1,2-Di(ethoxycarbonyl)ethyl) dimethyl phosphorothiolothionate
Diethyl ((dimethoxyphosphinothioyl)thio)butanedioate
Diethyl (dimethoxyphosphinothioylthio)succinate
Diethyl mercaptosuccinate, O,O-dimethyl dithiophosphate, S-ester
Diethyl mercaptosuccinate S-ester with O,O-dimethylphosphorodithioate
Diethyl(dimethoxythiophosphorylthio)succinate
((Dimethoxyphosphinothioyl)thio)butanedioic acid diethyl ester
O,O-Dimethyl S-(1,2-bis(ethoxycarbonyl)ethyl) dithiophosphate
O,O-Dimethyl S-(1,2-dicarbethoxyethyl) dithiophosphate
O,O-Dimethyl S-(1,2-dicarbethoxyethyl)phosphorodithioate
O,O-Dimethyl S-1,2-di(ethoxycarbamyl)ethyl phosphorodithioate
O,O-Dimethyl-S-1,2-(dicarbaethoxyaethyl)-dithiophosphat [German]
O,O-Dimethyl-S-1,2-dikarbetoxylethylditiofosfat [Czech]
O,O-Dimethyldithiophosphate diethylmercaptosuccinate
Dithiophosphate de O,O-dimethyle et de S-(1,2-dicarboethoxyethyle) [French]
Dorthion
O,O-Dwumetylo-S-1,2-bis(karboetoksyetylo)-dwutiofosforan [Polish]
EINECS 204-497-7
EL 4049
Emmatos Extra
Ethiolacar
Etiol
Extermathion
Flair
Forthion
Fosfothion
Fosfotion
Fosfotion 550
Fyfanon
Hilthion
HSDB 665
IFO 13140
Insecticide No. 4049
Karbofos
Kill-A-Mite
Kop-thion
Kypfos
Latka 4049 [Czech]
Malacide
Malafor
Malagran
Malakill
Malamar
Malamar 50
Malaphos
Malasol
Malaspray
Malataf
Malathiazol
Malathion E50
Malathion LV concentrate
Malathon
Malathyl
Malation [Polish]
Malatol
Malatox
Malmed
Malphos
Mercaptosuccinic acid diethyl ester
Mercaptothion
Mercaptotion [Spanish]
Moscarda
NCI-C00215
NSC 6524
Oleophosphothion
Ortho malathion
Phosphorodithioic acid, O,O-dimethyl ester, S-ester with diethyl mercaptosuccinate
Phosphothion
Prioderm
Sadofos
Sadophos
SF 60
Siptox I
Succinic acid, mercapto-, diethyl ester, S-ester with O,O-dimethyl phosphorodithioate
Sumitox
TAK
Taskil
UN 2783
Maldison
Ovide
Dithiophosphate de O,O-dimethyle et de S-(1,2-dicarboethoxyethyle)
Latka 4049
Malation
Mercaptotion
O,O-Dimethyl-S-1,2-(dicarbaethoxyaethyl)-dithiophosphat
O,O-Dimethyl-S-1,2-dikarbetoxylethylditiofosfat
O,O-Dwumetylo-S-1,2-bis(karboetoksyetylo)-dwutiofosforan
S-(1,2-Bis(aethoxy-carbonyl)-aethyl)-O,O-dimethyl-dithiophosphat
S-(1,2-Bis(ethoxy-carbonyl)-ethyl)-O,O-dimethyl-dithiofosfaat
S-(1,2-Bis(etossi-carbonil)-etil)-O,O-dimetil-ditiofosfato
UNII-U5N7SU872W
Disclaimer: Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. We do not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.