Question

I am a breastfeeding mother and i want to know if it is safe to use 6-Mercapto-2-aminopurine? Is 6-Mercapto-2-aminopurine safe for nursing mother and child? Does 6-Mercapto-2-aminopurine extracts into breast milk? Does 6-Mercapto-2-aminopurine has any long term or short term side effects on infants? Can 6-Mercapto-2-aminopurine influence milk supply or can 6-Mercapto-2-aminopurine decrease milk supply in lactating mothers?

6-Mercapto-2-aminopurine lactation summary

6-Mercapto-2-aminopurine is dangerous in breastfeeding
  • DrLact safety Score for 6-Mercapto-2-aminopurine is 7 out of 8 which is considered Dangerous as per our analyses.
  • A safety Score of 7 indicates that usage of 6-Mercapto-2-aminopurine may cause toxic or severe side effects in breastfed baby.
  • Our study of different scientific research indicates that 6-Mercapto-2-aminopurine may cause moderate to high side effects or may affect milk supply in lactating mother.
  • Our suggestion is to use safer alternate options rather than using 6-Mercapto-2-aminopurine .
  • Usage of 6-Mercapto-2-aminopurine is in contradiction to breastfeeding hence if it is must to use 6-Mercapto-2-aminopurine and there is no better alternative available then breastfeeding shall be stopped permanently or temporarily.
  • Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.

Answer by Dr. Ru: About 6-Mercapto-2-aminopurine usage in lactation

Indicated for treatment of leukemia.

Answer by DrLact: About 6-Mercapto-2-aminopurine usage in lactation

Most sources consider breastfeeding to be contraindicated during maternal antineoplastic drug therapy, although antimetabolites such as 6-Mercapto-2-aminopurine appear to pose the least risk to breastfed infants.[1] 6-Mercapto-2-aminopurine levels in milk are reportedly low. 6-Mercapto-2-aminopurine nucleosides are active intracellular metabolites of azathioprine and have been measured in breastmilk and in infant serum following maternal use of azathioprine as an immunosuppressant. Although amounts in milk were low in breastmilk and mostly undetectable in infant serum, relatively low dosages of azathioprine were used. After high-dose chemotherapy, it might be possible to breastfeed safely during intermittent therapy with an appropriate period of breastfeeding abstinence. Although no data are available to determine an appropriate period to withhold breastfeeding, the drug's terminal half-life suggests that withholding breastfeeding for 4 days may be sufficient. Chemotherapy may adversely affect the normal microbiome and chemical makeup of breastmilk.[2]

6-Mercapto-2-aminopurine Side Effects in Breastfeeding

6-Mercapto-2-aminopurine is an active metabolite of azathioprine. Numerous infants breastfed during maternal azathioprine in dosages up to 250 mg daily have been reported with no adverse effects noted. See Azathioprine record for details.

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