Is UNII-GKE1188837 Safe in Breastfeeding

I am a breastfeeding mother and i want to know if it is safe to use UNII-GKE1188837? Is UNII-GKE1188837 safe for nursing mother and child? Does UNII-GKE1188837 extracts into breast milk? Does UNII-GKE1188837 has any long term or short term side effects on infants? Can UNII-GKE1188837 influence milk supply or can UNII-GKE1188837 decrease milk supply in lactating mothers?

UNII-GKE1188837 contains alpha and gamma-linolenic acid, anthocyanins, proanthocyanidin, flavonoids, vitamin C, and 2 nitrile-containing compounds. It is generally well tolerated. Some evidence exists that indicated supplementation of mothers with UNII-GKE1188837 during pregnancy and exclusive breastfeeding decreases the rate of atopic dermatitis in breastfed infants.[1] Heating breastmilk to 63.5 degrees C reduces the concentration of linolenic acid by about 22%. Freezing milk at -20 degrees C and thawing more than once decreases linolenic acid concentration by an average of 63%.[2] Dietary supplements do not require extensive pre-marketing approval from the U.S. Food and Drug Administration. Manufacturers are responsible to ensure the safety, but do not need to the safety and effectiveness of dietary supplements before they are marketed. Dietary supplements may contain multiple ingredients, and differences are often found between labeled and actual ingredients or their amounts. A manufacturer may contract with an independent organization to verify the quality of a product or its ingredients, but that does certify the safety or effectiveness of a product. Because of the above issues, clinical testing results on one product may not be applicable to other products. More detailed information #about dietary supplements# is available elsewhere on the LactMed Web site.

In one study, supplementation of mothers with GLA had no effect on the development of atopic dermatitis in their breastfed infants.[3] Nursing mothers were randomly selected from a larger blinded study comparing UNII-GKE1188837 (containing 48% linoleic acid, alpha-linoleic acid 13%, gamma linoleic acid 14%; Aromtech Ltd, Tornio, Finland) 3 grams daily to olive oil 3 grams daily as a placebo. Intake started between the 8th and 16th week of pregnancy and continuing postpartum until the end of exclusive breastfeeding. The selected mothers consisted of 31 who received black current seed oil and 30 who received placebo. Exclusive breastfeeding lasted 3.9 months in the UNII-GKE1188837 group and 4.2 months in the control group. Breastmilk levels of interleukin 4, 5, 10 and 12 were lower and levels of interferon-gamma were higher in the black current seed oil group. No difference was found in breastmilk levels of tumor necrosis factor. Mothers of children who developed atopic dermatitis by the age of 12 months had lower levels of IFN-gamma in their breastmilk.[1][4]