Is Levobunolol Safe in Breastfeeding
Question
I am a breastfeeding mother and i want to know if it is safe to use Levobunolol? Is Levobunolol safe for nursing mother and child? Does Levobunolol extracts into breast milk? Does Levobunolol has any long term or short term side effects on infants? Can Levobunolol influence milk supply or can Levobunolol decrease milk supply in lactating mothers?
Levobunolol lactation summary
- DrLact safety Score for Levobunolol is 3 out of 8 which is considered Low Risk as per our analyses.
- A safety Score of 3 indicates that usage of Levobunolol may cause some minor side effects in breastfed baby.
- Our study of different scientific research indicates that Levobunolol may cause moderate to no side effects in lactating mother.
- Most of scientific studies and research papers declaring usage of Levobunolol low risk in breastfeeding are based on normal dosage and may not hold true for higher dosage.
- While using Levobunolol We suggest monitoring child for possible reactions. It is also important to understand that side effects vary largely based on age of breastfed child and time of medication in addition to dosage.
- Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.
Answer by Dr. Ru: About Levobunolol usage in lactation
Systemic absorption is minimal. There have not been problems except when a maternal overdose has been absorbed. Like most ophthalmologic compounds for topical use a low dose and poor absorption make it compatible with breastfeeding.
Answer by DrLact: About Levobunolol usage in lactation
Based on its physicochemical properties and its ophthalmic route of administration, levobunolol appears to present a moderately low risk to the breastfed infant. To substantially diminish the amount of drug that reaches the breastmilk after using eye drops, place pressure over the tear duct by the corner of the eye for 1 minute or more, then remove the excess solution with an absorbent tissue.
Levobunolol Side Effects in Breastfeeding
A study of mothers taking beta-blockers during nursing found a numerically, but not statistically significant increased number of adverse reactions in those taking any beta-blocker. Although the ages of infants were matched to control infants, the ages of the affected infants were not stated. None of the mothers were taking levobunolol.[2]
Levobunolol Possible Effects in Breastfeeding
Relevant published information on the effects of beta-blockade or levobunolol during normal lactation was not found as of the revision date. A study in 6 patients with hyperprolactinemia and galactorrhea found no changes in serum prolactin levels following beta-adrenergic blockade with propranolol.[3]
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Timolol(Safe)
Metoprolol(Safe)
Sotalol(Low Risk)
Bisoprolol(Low Risk)
Propranolol(Safe)
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