Question

I am a breastfeeding mother and i want to know if it is safe to use Entyvio? Is Entyvio safe for nursing mother and child? Does Entyvio extracts into breast milk? Does Entyvio has any long term or short term side effects on infants? Can Entyvio influence milk supply or can Entyvio decrease milk supply in lactating mothers?

Answer by DrLact: About Entyvio usage in lactation

Limited information indicates that maternal Entyvio injections produce low levels in breastmilk and does not adversely affect the nursing infant. Because Entyvio is a large protein molecule with a molecular weight of about 147,000, absorption is unlikely because it is probably destroyed in the infant's gastrointestinal tract. Until more data become available, Entyvio should be used with caution during breastfeeding, especially while nursing a newborn or preterm infant.

Entyvio Side Effects in Breastfeeding

Eight women who were receiving Entyvio for inflammatory bowel disease were breastfeeding their infants (extent not stated). Dosages were 300 mg intravenously, at 1 to 2 month intervals for 6 and starting during induction for 2 women. No increase in general or gastrointestinal tract infections were seen in the newborns up to 10 months of age and all infants reached their development milestones.[1] Five infants were breastfed by mothers receiving Entyvio 300 mg intravenously at regular intervals. The infants all had normal developmental milestones at 3.5 to 10 months of age. All of the infants routine inactive vaccines without complications.[2]
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