Is LY-248686 Safe in Breastfeeding
Question
I am a breastfeeding mother and i want to know if it is safe to use LY-248686? Is LY-248686 safe for nursing mother and child? Does LY-248686 extracts into breast milk? Does LY-248686 has any long term or short term side effects on infants? Can LY-248686 influence milk supply or can LY-248686 decrease milk supply in lactating mothers?
LY-248686 lactation summary
- DrLact safety Score for LY-248686 is 1 out of 8 which is considered Safe as per our analyses.
- A safety Score of 1 indicates that usage of LY-248686 is mostly safe during lactation for breastfed baby.
- Our study of different scientific research also indicates that LY-248686 does not cause any serious side effects in breastfeeding mothers.
- Most of scientific studies and research papers declaring usage of LY-248686 safe in breastfeeding are based on normal dosage and may not hold true for higher dosage.
- Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.
Answer by Dr. Ru: About LY-248686 usage in lactation
It is a reuptake-inhibitor of Serotonin and Norepinephrine. Excreted into breast milk in clinically non-significant amount with no side-effects being observed in breastfed infants from treated mothers. Plasma level in those infants was very low or undetectable. Because there is less experience published than with other antidepressants of the same pharmacological group, it should be preferred the use of an alternative drug that is known to be safer in the neonatal period or prematurity. Galactorrhea has been observed but less frequently than with other antidepressants. Women who use antidepressant medication during pregnancy are in need of more support for breastfeeding since they are at risk for early weaning.