Is LY 2951742 Safe in Breastfeeding
Question
I am a breastfeeding mother and i want to know if it is safe to use LY 2951742? Is LY 2951742 safe for nursing mother and child? Does LY 2951742 extracts into breast milk? Does LY 2951742 has any long term or short term side effects on infants? Can LY 2951742 influence milk supply or can LY 2951742 decrease milk supply in lactating mothers?
Answer by DrLact: About LY 2951742 usage in lactation
No information is available on the clinical use of LY 2951742 during breastfeeding. Because LY 2951742 is a large protein molecule with a molecular weight of about 147,000, the amount in milk is likely to be very low and absorption is unlikely because it is probably destroyed in the infant's gastrointestinal tract. Until more data become available, LY 2951742 should be used with caution during breastfeeding, especially while nursing a newborn or preterm infant. LY 2951742 is a human immunoglobulin G1 (IgG4) antibody. Holder pasteurization (62.5 degrees C for 30 minutes) decreases the concentration of endogenous immunoglobulin G in mature milk by 60 to 79%.[1][2] A study of 67 colostrum samples that underwent Holder pasteurization found that IgG amounts decreased by 34 to 40%. Specific IgG subclasses decreased by different amounts, with IgG4 activity decreasing by about %.[3] None of the studies measured IgG activity.
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