Question

I am a breastfeeding mother and i want to know if it is safe to use TL 353? Is TL 353 safe for nursing mother and child? Does TL 353 extracts into breast milk? Does TL 353 has any long term or short term side effects on infants? Can TL 353 influence milk supply or can TL 353 decrease milk supply in lactating mothers?

TL 353 lactation summary

TL 353 usage has low risk in breastfeeding
  • DrLact safety Score for TL 353 is 3 out of 8 which is considered Low Risk as per our analyses.
  • A safety Score of 3 indicates that usage of TL 353 may cause some minor side effects in breastfed baby.
  • Our study of different scientific research indicates that TL 353 may cause moderate to no side effects in lactating mother.
  • Most of scientific studies and research papers declaring usage of TL 353 low risk in breastfeeding are based on normal dosage and may not hold true for higher dosage.
  • While using TL 353 We suggest monitoring child for possible reactions. It is also important to understand that side effects vary largely based on age of breastfed child and time of medication in addition to dosage.
  • Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.

Answer by Dr. Ru: About TL 353 usage in lactation

Anti-inflammatory and immunomodulator used in the treatment of psoriasis and in relapsing forms of multiple sclerosis. Since the last update we have not found published data on its excretion in breast milk. Its pharmacokinetic data (large volume of distribution and short half-life) make it unlikely that milk would pass through in significant quantities (Almas 2016).Possible side effects are rare and generally not serious, with no immunosuppressive effects or higher frequency of infections (EMA 2017, AEMPS 2015). Until there is more published data on this drug in relation to breastfeeding, known safer alternatives may be preferable, especially during the neonatal period and in case of prematurity (Brown 2017, Yiu 2015, Bove 2014, Cree 2013).

Answer by DrLact: About TL 353 usage in lactation

There is no published experience with TL 353 during breastfeeding. Although some authors recommend avoiding breastfeeding during TL 353 therapy,[1][2] others and the manufacturer do not.[3] Avoiding breastfeeding for 4 to 5 hours after a dose should minimize infant exposure. The infant should be monitored for adequate weight gain, and developmental milestones, especially in younger, exclusively breastfed infants. Some authors also recommend monitoring for vomiting and diarrhea.[3]
Disclaimer: Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. We do not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.