Question

I am a breastfeeding mother and i want to know if it is safe to use 1-De(5-oxo-L-proline)-2-de-L-glutamine-5-L-methioninecaerulein? Is 1-De(5-oxo-L-proline)-2-de-L-glutamine-5-L-methioninecaerulein safe for nursing mother and child? Does 1-De(5-oxo-L-proline)-2-de-L-glutamine-5-L-methioninecaerulein extracts into breast milk? Does 1-De(5-oxo-L-proline)-2-de-L-glutamine-5-L-methioninecaerulein has any long term or short term side effects on infants? Can 1-De(5-oxo-L-proline)-2-de-L-glutamine-5-L-methioninecaerulein influence milk supply or can 1-De(5-oxo-L-proline)-2-de-L-glutamine-5-L-methioninecaerulein decrease milk supply in lactating mothers?

Answer by DrLact: About 1-De(5-oxo-L-proline)-2-de-L-glutamine-5-L-methioninecaerulein usage in lactation

1-De(5-oxo-L-proline)-2-de-L-glutamine-5-L-methioninecaerulein is a synthetic octapeptide analogue of cholecystokinin. Because 1-De(5-oxo-L-proline)-2-de-L-glutamine-5-L-methioninecaerulein has a molecular weight of 1143, the amount in milk is likely to be very low and oral absorption by the infant is unlikely because it is probably destroyed in the infant's gastrointestinal tract. The serum half-life of 1-De(5-oxo-L-proline)-2-de-L-glutamine-5-L-methioninecaerulein is less than 2 minutes, indicating that withholding breastfeeding for 10 minutes after a dose should ensure that the infant is not exposed to the drug.
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