Question

I am a breastfeeding mother and i want to know if it is safe to use IMC 11F8? Is IMC 11F8 safe for nursing mother and child? Does IMC 11F8 extracts into breast milk? Does IMC 11F8 has any long term or short term side effects on infants? Can IMC 11F8 influence milk supply or can IMC 11F8 decrease milk supply in lactating mothers?

Answer by DrLact: About IMC 11F8 usage in lactation

No information is available on the clinical use of IMC 11F8 during breastfeeding. Because IMC 11F8 is a large protein molecule with a molecular weight of 145,000, the amount in milk is likely to be very low and absorption is unlikely because it is probably destroyed in the infant's gastrointestinal tract. However, the manufacturer recommends that women receiving IMC 11F8 should not breastfeed during therapy or for 3 months following the final dose. IMC 11F8 is a human immunoglobulin G1 (IgG1) kappa antibody. Holder pasteurization (62.5 degrees C for 30 minutes) decreases the concentration of endogenous immunoglobulin G by up to 79%.[1][2] A study of 67 colostrum samples that underwent Holder pasteurization found that IgG amounts decreased by 34 to 40%. Specific IgG subclasses decreased by different amounts, with IgG1 activity decreasing by about 37%.[3] None of the studies measured IgG activity.

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