Question

I am a breastfeeding mother and i want to know if it is safe to use UNII-2BT4C47RUI? Is UNII-2BT4C47RUI safe for nursing mother and child? Does UNII-2BT4C47RUI extracts into breast milk? Does UNII-2BT4C47RUI has any long term or short term side effects on infants? Can UNII-2BT4C47RUI influence milk supply or can UNII-2BT4C47RUI decrease milk supply in lactating mothers?

Answer by DrLact: About UNII-2BT4C47RUI usage in lactation

No information is available on the clinical use of UNII-2BT4C47RUI during breastfeeding. Because UNII-2BT4C47RUI is a large protein molecule with a molecular weight of 145,000, the amount in milk is likely to be very low and absorption is unlikely because it is probably destroyed in the infant's gastrointestinal tract. However, the manufacturer recommends that women receiving UNII-2BT4C47RUI should not breastfeed during therapy or for 3 months following the final dose. UNII-2BT4C47RUI is a human immunoglobulin G1 (IgG1) kappa antibody. Holder pasteurization (62.5 degrees C for 30 minutes) decreases the concentration of endogenous immunoglobulin G by up to 79%.[1][2] A study of 67 colostrum samples that underwent Holder pasteurization found that IgG amounts decreased by 34 to 40%. Specific IgG subclasses decreased by different amounts, with IgG1 activity decreasing by about 37%.[3] None of the studies measured IgG activity.

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