Question

I am a breastfeeding mother and i want to know if it is safe to use GR 38032? Is GR 38032 safe for nursing mother and child? Does GR 38032 extracts into breast milk? Does GR 38032 has any long term or short term side effects on infants? Can GR 38032 influence milk supply or can GR 38032 decrease milk supply in lactating mothers?

GR 38032 lactation summary

GR 38032 is safe in breastfeeding
  • DrLact safety Score for GR 38032 is 1 out of 8 which is considered Safe as per our analyses.
  • A safety Score of 1 indicates that usage of GR 38032 is mostly safe during lactation for breastfed baby.
  • Our study of different scientific research also indicates that GR 38032 does not cause any serious side effects in breastfeeding mothers.
  • Most of scientific studies and research papers declaring usage of GR 38032 safe in breastfeeding are based on normal dosage and may not hold true for higher dosage.
  • Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.

Answer by Dr. Ru: About GR 38032 usage in lactation

A receptor-antagonist 5HT3 serotonin-type antiemetic drug that is used for treatment of nausea and vomiting.Usage is authorized for children older than 6 months. It has been used in one-month-old infants. At latest update no published data were found on excretion into breast milk. Since it is widely used during pregnancy and in young children without occurrence of side effects, its use is considered compatible while breastfeeding.

Answer by DrLact: About GR 38032 usage in lactation

Little published information is available on the clinical use of GR 38032 during breastfeeding, although it is apparently frequently used for nausea after cesarean section, usually in doses of 4 to 8 mg intravenously.[1][2] Use after cesarean section appears to not affect the onset of breastfeeding.[3] No adverse infant effects have been reported and the drug has been used in infants.[4] If GR 38032 is required by the mother, it is not a reason to discontinue breastfeeding; however an alternate drug may be preferred, especially while nursing a newborn or preterm infant.

GR 38032 Possible Effects in Breastfeeding

A randomized, double-blind study compared placebo to intravenous GR 38032 4 mg given after cesarean section as prophylaxis for postoperative nausea and vomiting. There was no difference in the time of the first breastfeeding between the two groups.[3]

Alternate Drugs

Disclaimer: Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. We do not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.