Is Hepatitis B immunoglobulins Safe in Breastfeeding

I am a breastfeeding mother and i want to know if it is safe to use Hepatitis B immunoglobulins? Is Hepatitis B immunoglobulins safe for nursing mother and child? Does Hepatitis B immunoglobulins extracts into breast milk? Does Hepatitis B immunoglobulins has any long term or short term side effects on infants? Can Hepatitis B immunoglobulins influence milk supply or can Hepatitis B immunoglobulins decrease milk supply in lactating mothers?

Hepatitis B immune globulin is an immune globulin (IgG) rich in IgG antibodies against hepatis B. IgG is a normal component of breastmilk. No special precautions are required during breastfeeding. Hepatitis B immune globulin is recommended along with hepatitis B vaccine to be given to infants of mothers who are positive for hepatitis B surface antigen. No differences exist in infection rates between breast-fed and formula-fed infants born to hepatitis B-infected women, as long as the infant receives these preventative measures at birth. Mothers with hepatitis B are encouraged to breastfeed their infants after their infants receive these preventative measures.[1][2] Holder pasteurization (62.5 degrees C for 30 minutes) decreases the concentration of endogenous immunoglobulin G by up to 79%.[3][4] Higher temperatures of 72 and 85 degrees C appear to cause greater loss, but further lyophylization does not cause marked additional loss.[5] A flash heating pasteurization reduced the concentration of endogenous immunoglobulin G by 33%.[6] A continuous flow, high-temperature short-time (HTST) pasteurizer at temperatures ranging from 71 to 74 degrees C retained from about 38 to 79% of IgG activity depending on the temperature and exposure time.[7] A study of 67 colostrum samples that underwent Holder pasteurization found that IgG amounts decreased by 34 to 40%. Immunoreactivity against ovalbumin decreased by 4 to 18% and immunoreactivity against tetanus toxoid decreased by 8 to 20%. Specific IgG subclasses decreased by different amounts, with IgG4 retaining all of its activity and IgG1 and 2 decreasing by about 40 to 50%.[8]