Question

I am a breastfeeding mother and i want to know if it is safe to use Pyrimethamine? Is Pyrimethamine safe for nursing mother and child? Does Pyrimethamine extracts into breast milk? Does Pyrimethamine has any long term or short term side effects on infants? Can Pyrimethamine influence milk supply or can Pyrimethamine decrease milk supply in lactating mothers?

Pyrimethamine lactation summary

Pyrimethamine is safe in breastfeeding
  • DrLact safety Score for Pyrimethamine is 1 out of 8 which is considered Safe as per our analyses.
  • A safety Score of 1 indicates that usage of Pyrimethamine is mostly safe during lactation for breastfed baby.
  • Our study of different scientific research also indicates that Pyrimethamine does not cause any serious side effects in breastfeeding mothers.
  • Most of scientific studies and research papers declaring usage of Pyrimethamine safe in breastfeeding are based on normal dosage and may not hold true for higher dosage.
  • Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.

Answer by Dr. Ru: About Pyrimethamine usage in lactation

Used as treatment of malaria and toxoplasmosis. Give folic acid or similar as pyrimethamine has an antagonistic effect on this vitamin. Avoid its use on patients suffering of G-6-P dehydrogenasa. American Academy of Pediatrics: Maternal Medication Usually Compatible With Breastfeeding.

Answer by DrLact: About Pyrimethamine usage in lactation

No adverse reactions in breastfed infants have been reported and it is acceptable in nursing mothers. In HIV-infected women, elevated viral HIV loads in milk were decreased after treatment with chloroquine to a greater extent than other women who were treated with the combination of sulfadoxine and pyrimethamine.[1] It has been suggested that maternal pyrimethamine clearance might be increased during lactation, but data are insufficient to make a definitive conclusion.[2][3]

Pyrimethamine Side Effects in Breastfeeding

Administration of pyrimethamine to mothers of 26 predominantly breastfed infants 2 to 6 months old who were infected with malaria was curative in the infants.[5] The regimen consisted of 75 mg followed by a subsequent dose of 50-75 mg 4 to 7 days later. The efficacy apparently is related to breastfeeding habits, because infants in another tribal group who breastfed their infants less extensively were not protected.[4] A case report indicates that a maternal dose of 75 mg orally followed by 25 mg weekly cured malaria in her breastfed infant and protected her infant against becoming infected with malaria for 6 months. After the mother missed taking her dose for 2 weeks, the infant developed symptoms of malaria.[7] No adverse effects were reported in any of the infants.

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Disclaimer: Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. We do not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.