Question

I am a breastfeeding mother and i want to know if it is safe to use UNII-52CMI0WC3Y? Is UNII-52CMI0WC3Y safe for nursing mother and child? Does UNII-52CMI0WC3Y extracts into breast milk? Does UNII-52CMI0WC3Y has any long term or short term side effects on infants? Can UNII-52CMI0WC3Y influence milk supply or can UNII-52CMI0WC3Y decrease milk supply in lactating mothers?

Answer by DrLact: About UNII-52CMI0WC3Y usage in lactation

No information is available on the clinical use of UNII-52CMI0WC3Y during breastfeeding. Because UNII-52CMI0WC3Y is a large protein molecule with a molecular weight of 145,000, the amount in milk is likely to be very low and absorption is unlikely because it is probably destroyed in the infant's gastrointestinal tract. Until more data become available, UNII-52CMI0WC3Y should be used with caution or avoided during breastfeeding, especially while nursing a newborn or preterm infant. The manufacturer recommends that breastfeeding be discontinued during UNII-52CMI0WC3Y therapy and for at least 5 months after the last dose. UNII-52CMI0WC3Y is a human immunoglobulin G1 (IgG1) antibody. Holder pasteurization (62.5 degrees C for 30 minutes) decreases the concentration of endogenous immunoglobulin G in mature milk by 60 to 79%.[1][2] A study of 67 colostrum samples that underwent Holder pasteurization found that IgG amounts decreased by 34 to 40%. Specific IgG subclasses decreased by different amounts, with IgG1 activity decreasing by about 37%.[3] None of the studies measured IgG activity.

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