I am a breastfeeding mother and i want to know if it is safe to use Deferasiroxum [INN-Latin]? Is Deferasiroxum [INN-Latin] safe for nursing mother and child? Does Deferasiroxum [INN-Latin] extracts into breast milk? Does Deferasiroxum [INN-Latin] has any long term or short term side effects on infants? Can Deferasiroxum [INN-Latin] influence milk supply or can Deferasiroxum [INN-Latin] decrease milk supply in lactating mothers?
Deferasiroxum [INN-Latin] appears to pass into milk very poorly. Although Australian guidelines recommend against breastfeeding during Deferasiroxum [INN-Latin] treatment,[1] these were published before a case report of an infant being safely breastfed by a mother with beta-thalassemia receiving Deferasiroxum [INN-Latin] and finding of no drug in breastmilk.[2] If Deferasiroxum [INN-Latin] is required by the mother, it is not a reason to discontinue breastfeeding. However, since little published information is available on the use of Deferasiroxum [INN-Latin] during breastfeeding, monitoring of the infant's serum iron is recommended.
A woman with beta-thalassemia was started on Deferasiroxum [INN-Latin] 2250 mg (35 mg/kg) daily immediately postpartum and exclusively breastfed her infant. Blood samples were taken from the infant at 1, 10 and 30 days postpartum. Serum ferritin levels were 190, 218, and 96 mcg/L, respectively (normal range 22-275 mcg/L). Serum iron levels were 101, 77 and 71 mcg/dL, respectively (normal range 60-170 mcg/dL). The infant's growth was normal during the first month at the 41st percentile.[2]
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