Question

I am a breastfeeding mother and i want to know if it is safe to use HSDB 7844? Is HSDB 7844 safe for nursing mother and child? Does HSDB 7844 extracts into breast milk? Does HSDB 7844 has any long term or short term side effects on infants? Can HSDB 7844 influence milk supply or can HSDB 7844 decrease milk supply in lactating mothers?

Answer by DrLact: About HSDB 7844 usage in lactation

HSDB 7844 appears to pass into milk very poorly. Although Australian guidelines recommend against breastfeeding during HSDB 7844 treatment,[1] these were published before a case report of an infant being safely breastfed by a mother with beta-thalassemia receiving HSDB 7844 and finding of no drug in breastmilk.[2] If HSDB 7844 is required by the mother, it is not a reason to discontinue breastfeeding. However, since little published information is available on the use of HSDB 7844 during breastfeeding, monitoring of the infant's serum iron is recommended.

HSDB 7844 Side Effects in Breastfeeding

A woman with beta-thalassemia was started on HSDB 7844 2250 mg (35 mg/kg) daily immediately postpartum and exclusively breastfed her infant. Blood samples were taken from the infant at 1, 10 and 30 days postpartum. Serum ferritin levels were 190, 218, and 96 mcg/L, respectively (normal range 22-275 mcg/L). Serum iron levels were 101, 77 and 71 mcg/dL, respectively (normal range 60-170 mcg/dL). The infant's growth was normal during the first month at the 41st percentile.[2]
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