Question

I am a breastfeeding mother and i want to know if it is safe to use Jadenu Sprinkle? Is Jadenu Sprinkle safe for nursing mother and child? Does Jadenu Sprinkle extracts into breast milk? Does Jadenu Sprinkle has any long term or short term side effects on infants? Can Jadenu Sprinkle influence milk supply or can Jadenu Sprinkle decrease milk supply in lactating mothers?

Answer by DrLact: About Jadenu Sprinkle usage in lactation

Jadenu Sprinkle appears to pass into milk very poorly. Although Australian guidelines recommend against breastfeeding during Jadenu Sprinkle treatment,[1] these were published before a case report of an infant being safely breastfed by a mother with beta-thalassemia receiving Jadenu Sprinkle and finding of no drug in breastmilk.[2] If Jadenu Sprinkle is required by the mother, it is not a reason to discontinue breastfeeding. However, since little published information is available on the use of Jadenu Sprinkle during breastfeeding, monitoring of the infant's serum iron is recommended.

Jadenu Sprinkle Side Effects in Breastfeeding

A woman with beta-thalassemia was started on Jadenu Sprinkle 2250 mg (35 mg/kg) daily immediately postpartum and exclusively breastfed her infant. Blood samples were taken from the infant at 1, 10 and 30 days postpartum. Serum ferritin levels were 190, 218, and 96 mcg/L, respectively (normal range 22-275 mcg/L). Serum iron levels were 101, 77 and 71 mcg/dL, respectively (normal range 60-170 mcg/dL). The infant's growth was normal during the first month at the 41st percentile.[2]
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