Is HSDB 8227 Safe in Breastfeeding
Question
I am a breastfeeding mother and i want to know if it is safe to use HSDB 8227? Is HSDB 8227 safe for nursing mother and child? Does HSDB 8227 extracts into breast milk? Does HSDB 8227 has any long term or short term side effects on infants? Can HSDB 8227 influence milk supply or can HSDB 8227 decrease milk supply in lactating mothers?
HSDB 8227 lactation summary
- DrLact safety Score for HSDB 8227 is 3 out of 8 which is considered Low Risk as per our analyses.
- A safety Score of 3 indicates that usage of HSDB 8227 may cause some minor side effects in breastfed baby.
- Our study of different scientific research indicates that HSDB 8227 may cause moderate to no side effects in lactating mother.
- Most of scientific studies and research papers declaring usage of HSDB 8227 low risk in breastfeeding are based on normal dosage and may not hold true for higher dosage.
- While using HSDB 8227 We suggest monitoring child for possible reactions. It is also important to understand that side effects vary largely based on age of breastfed child and time of medication in addition to dosage.
- Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.
Answer by Dr. Ru: About HSDB 8227 usage in lactation
Used alone or in combination with sofosbuvir in the treatment of hepatitis C. Since the last update we have not found published data on its excretion in breast milk. Its pharmacokinetic data (slightly elevated molecular weight and very high percentage of plasma protein binding) make it very unlikely that significant amounts will pass into milk, so that although there is disagreement (Thompson 2016), other experts believe that treatment with HSDB 8227, on its own or in combination with Sofosbuvir is not contraindicated during breastfeeding (LactMed 2016, See below the information of these related products:
Answer by DrLact: About HSDB 8227 usage in lactation
HSDB 8227 has not been studied in nursing mothers being treated for hepatitis C infection. Because it is greater than 99.9% bound to maternal plasma proteins, amounts in breastmilk are likely to be very low. If HSDB 8227 used alone or in combination with sofosbuvir is required by the mother, it is not a reason to discontinue breastfeeding. Some sources recommend against breastfeeding when HSDB 8227 is used with ribavirin. Hepatitis C is not transmitted through breastmilk[1][2] and breastmilk has been shown to inactivate hepatitis C virus (HCV).[3][4] However, the Centers for Disease Control recommends that mothers with HCV infection should consider abstaining from breastfeeding if their nipples are cracked or bleeding. It is not clear if this warning would apply to mothers who are being treated for hepatitis C. Infants born to mothers with HCV infection should be tested for HCV infection; because maternal antibody is present for the first 18 months of life and before the infant mounts an immunologic response, nucleic acid testing is recommended.[1][2]
Alternate Drugs
Ombitasvir(Low Risk)
Famciclovir(Low Risk)
Lamivudine(Safe)
Acyclovir(Safe)
Indinavir(Unsafe)
Daclatasvir(Low Risk)
Dasabuvir(Low Risk)
Emtricitabine(Safe)
Zanamivir(Safe)
Efavirenz(Unsafe)
Valganciclovir(Low Risk)
Zidovudine(Low Risk)
Didanosine(Unsafe)
Ganciclovir(Low Risk)
Tenofovir(Safe)
Velpatasvir(Low Risk)
Ribavirin(Low Risk)
Saquinavir(Unsafe)
Abacavir(Safe)
Simeprevir(Low Risk)
Ritonavir(Unsafe)
Oseltamivir(Safe)
Sofosbuvir(Low Risk)
Nevirapine(Low Risk)
Amantadine(Low Risk)
Nelfinavir(Unsafe)
Ledipasvir(Low Risk)
Penciclovir(Safe)
Simeprevir(Low Risk)