Question

I am a breastfeeding mother and i want to know if it is safe to use UNII-15C2VL427D? Is UNII-15C2VL427D safe for nursing mother and child? Does UNII-15C2VL427D extracts into breast milk? Does UNII-15C2VL427D has any long term or short term side effects on infants? Can UNII-15C2VL427D influence milk supply or can UNII-15C2VL427D decrease milk supply in lactating mothers?

Answer by DrLact: About UNII-15C2VL427D usage in lactation

This record refers to the use of intravitreal UNII-15C2VL427D for macular degeneration. No information is available on the use of UNII-15C2VL427D during breastfeeding. The manufacturer estimates that after intravitreal administration of 2 mg, the mean maximum plasma concentration of free UNII-15C2VL427D is more than 100-fold lower than the concentration of UNII-15C2VL427D required to half-maximally bind systemic vascular endothelial growth factor. Additionally, UNII-15C2VL427D is a large protein molecule with a molecular weight of 115,000, Therefore, the amount in breastmilk is likely to be clinically unimportant after intravitreal injection. However, the manufacturer recommends avoiding the drug during breastfeeding.
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