Question

I am a breastfeeding mother and i want to know if it is safe to use HSDB 8258? Is HSDB 8258 safe for nursing mother and child? Does HSDB 8258 extracts into breast milk? Does HSDB 8258 has any long term or short term side effects on infants? Can HSDB 8258 influence milk supply or can HSDB 8258 decrease milk supply in lactating mothers?

Answer by DrLact: About HSDB 8258 usage in lactation

This record refers to the use of intravitreal HSDB 8258 for macular degeneration. No information is available on the use of HSDB 8258 during breastfeeding. The manufacturer estimates that after intravitreal administration of 2 mg, the mean maximum plasma concentration of free HSDB 8258 is more than 100-fold lower than the concentration of HSDB 8258 required to half-maximally bind systemic vascular endothelial growth factor. Additionally, HSDB 8258 is a large protein molecule with a molecular weight of 115,000, Therefore, the amount in breastmilk is likely to be clinically unimportant after intravitreal injection. However, the manufacturer recommends avoiding the drug during breastfeeding.
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