Is UNII-621G617227 Safe in Breastfeeding
Question
I am a breastfeeding mother and i want to know if it is safe to use UNII-621G617227? Is UNII-621G617227 safe for nursing mother and child? Does UNII-621G617227 extracts into breast milk? Does UNII-621G617227 has any long term or short term side effects on infants? Can UNII-621G617227 influence milk supply or can UNII-621G617227 decrease milk supply in lactating mothers?
UNII-621G617227 lactation summary
- DrLact safety Score for UNII-621G617227 is 3 out of 8 which is considered Low Risk as per our analyses.
- A safety Score of 3 indicates that usage of UNII-621G617227 may cause some minor side effects in breastfed baby.
- Our study of different scientific research indicates that UNII-621G617227 may cause moderate to no side effects in lactating mother.
- Most of scientific studies and research papers declaring usage of UNII-621G617227 low risk in breastfeeding are based on normal dosage and may not hold true for higher dosage.
- While using UNII-621G617227 We suggest monitoring child for possible reactions. It is also important to understand that side effects vary largely based on age of breastfed child and time of medication in addition to dosage.
- Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.
Answer by Dr. Ru: About UNII-621G617227 usage in lactation
Antimuscarinic agent with atropine-like action. It is metabolized in Tolterodine At latest update no published data on excretion into breast milk were found. Until more published data on this drug in relation to breastfeeding is available, a known safer alternative as Tolterodine should be preferred with more favorable pharmacokinetics characteristics for lactation (e.g. high protein-binding capacity, faster elimination and lower oral bioavailability), particularly during the neonatal period and prematurity case. Take as smallest dose as possible and avoid long-term use since anticholinergics can reduce milk production. Monitoring anticholinergic symptoms in infants (dry mouth, constipation ..) is warranted.
Answer by DrLact: About UNII-621G617227 usage in lactation
No information is available on the use of UNII-621G617227 during breastfeeding. Long-term use of UNII-621G617227 might reduce milk production or milk letdown. During long-term use, observe for signs of decreased lactation (e.g., insatiety, poor weight gain).
UNII-621G617227 Possible Effects in Breastfeeding
Relevant published information in nursing mothers was not found as of the revision date. Anticholinergics can inhibit lactation in animals apparently by inhibiting growth hormone and oxytocin secretion.[1][2][3][4][5] Anticholinergic drugs can also reduce serum prolactin in nonnursing women.[6] The prolactin level in a mother with established lactation may not affect her ability to breastfeed.
Alternate Drugs
Fesoterodine(Low Risk)
Ipratropium(Safe)
Oxybutinyn(Low Risk)
Glycopyrrolate(Unsafe)
Atropine(Safe)
Tropicamide(Low Risk)
Dicyclomine(Unsafe)
Cyclopentolate(Low Risk)
Tolterodine(Low Risk)
Solifenacin(Unsafe)
Flavoxate(Low Risk)
Scopolamine(Low Risk)
Ipratropium(Safe)
Oxybutinyn(Low Risk)
Glycopyrrolate(Unsafe)
Atropine(Safe)
Tropicamide(Low Risk)
Dicyclomine(Unsafe)
Cyclopentolate(Low Risk)
Tolterodine(Low Risk)
Solifenacin(Unsafe)
Flavoxate(Low Risk)
Scopolamine(Low Risk)
Fesoterodine(Low Risk)