Is UNII-7RN5DR86CK Safe in Breastfeeding

I am a breastfeeding mother and i want to know if it is safe to use UNII-7RN5DR86CK? Is UNII-7RN5DR86CK safe for nursing mother and child? Does UNII-7RN5DR86CK extracts into breast milk? Does UNII-7RN5DR86CK has any long term or short term side effects on infants? Can UNII-7RN5DR86CK influence milk supply or can UNII-7RN5DR86CK decrease milk supply in lactating mothers?

• DrLact safety Score for UNII-7RN5DR86CK is 5 out of 8 which is considered Unsafe as per our analyses.
• A safety Score of 5 indicates that usage of UNII-7RN5DR86CK may cause serious side effects in breastfed baby.
• Our study of different scientific research indicates that UNII-7RN5DR86CK may cause moderate to high side effects or may affect milk supply in lactating mother.
• Our suggestion is to use safer alternate options rather than using UNII-7RN5DR86CK .
• It is recommended to evaluate the advantage of not breastfeeding while using UNII-7RN5DR86CK Vs not using UNII-7RN5DR86CK And continue breastfeeding.
• While using UNII-7RN5DR86CK Its must to monitor child for possible reactions. It is also important to understand that side effects vary largely based on age of breastfed child and time of medication in addition to dosage.
• Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.

Inhibitor of BCR-ABL and SRC tyrosine kinase that is used for treatment of several neoplastic diseases. At latest update, relevant published data on excretion into breast milk were not found. Because of high serum protein-binding capacity, excretion into breast milk in significant amount is seemingly unlikely. If continuation of safely breastfeeding is desired without assuming high risk for potentially severe side-effects, elimination of total burden of drug should be kept. For this to happen, it should be wait for 10 half-lives (T ½). It means that 13 days should be waited before resuming breastfeeding. Meanwhile, frequent pump-and-dump is recommended for maintenance of milk production.

No information is available on the clinical use of UNII-7RN5DR86CK during breastfeeding. Because UNII-7RN5DR86CK is more than 99% bound to plasma proteins, the amount in milk is likely to be low. However, its half-life is about 31 hours and it might accumulate in the infant. The manufacturer recommends that breastfeeding be discontinued during UNII-7RN5DR86CK therapy and for 2 weeks after the final dose.