Question

I am a breastfeeding mother and i want to know if it is safe to use Methyl (3Z)-3-(((4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenyl)amino)(phenyl)methylidene)-2-oxo-2,3-dihydro-1h-indole-6-carboxylate? Is Methyl (3Z)-3-(((4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenyl)amino)(phenyl)methylidene)-2-oxo-2,3-dihydro-1h-indole-6-carboxylate safe for nursing mother and child? Does Methyl (3Z)-3-(((4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenyl)amino)(phenyl)methylidene)-2-oxo-2,3-dihydro-1h-indole-6-carboxylate extracts into breast milk? Does Methyl (3Z)-3-(((4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenyl)amino)(phenyl)methylidene)-2-oxo-2,3-dihydro-1h-indole-6-carboxylate has any long term or short term side effects on infants? Can Methyl (3Z)-3-(((4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenyl)amino)(phenyl)methylidene)-2-oxo-2,3-dihydro-1h-indole-6-carboxylate influence milk supply or can Methyl (3Z)-3-(((4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenyl)amino)(phenyl)methylidene)-2-oxo-2,3-dihydro-1h-indole-6-carboxylate decrease milk supply in lactating mothers?

Answer by DrLact: About Methyl (3Z)-3-(((4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenyl)amino)(phenyl)methylidene)-2-oxo-2,3-dihydro-1h-indole-6-carboxylate usage in lactation

No information is available on the clinical use of Methyl (3Z)-3-(((4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenyl)amino)(phenyl)methylidene)-2-oxo-2,3-dihydro-1h-indole-6-carboxylate during breastfeeding. Because Methyl (3Z)-3-(((4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenyl)amino)(phenyl)methylidene)-2-oxo-2,3-dihydro-1h-indole-6-carboxylate is more than 97% bound to plasma proteins, the amount in milk is likely to be low. However, its half-life is about 9.7 hours and it might accumulate in the infant. The manufacturer recommends that breastfeeding be discontinued during Methyl (3Z)-3-(((4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenyl)amino)(phenyl)methylidene)-2-oxo-2,3-dihydro-1h-indole-6-carboxylate therapy.

Alternate Drugs

Dacarbazine(Dangerous)
Paclitaxel(Dangerous)
Cyclophosphamide(Dangerous)
Dasatinib(Unsafe)
Fluorouracil(Dangerous)
Cisplatin(Unsafe)
Docetaxel(Dangerous)
Alemtuzumab(Low Risk)
Dactinomycin(Dangerous)
Busulfan(Dangerous)
Rituximab(Low Risk)
Gemcitabine(Dangerous)
Bevacizumab(Low Risk)
Thioguanine(Dangerous)
Nilotinib(Unsafe)
Pazopanib(Unsafe)
Vincristine(Dangerous)
Tamoxifen(Dangerous)
Erlotinib(Unsafe)
Letrozole(Dangerous)
Mitoxantrone(Dangerous)
Trastuzumab(Unsafe)
Exemestane(Dangerous)
Cladribine(Dangerous)
Nivolumab(Unsafe)
Vinblastine(Dangerous)
Ipilimumab(Unsafe)
Hydroxyurea(Low Risk)
Bleomycin(Dangerous)
Cetuximab(Unsafe)
Etoposide(Dangerous)
Vinorelbine(Dangerous)
Imatinib(Unsafe)
Carboplatin(Dangerous)
Doxorubicin(Dangerous)
Dasatinib(Unsafe)
Gemcitabine(Dangerous)
Orlistat(Low Risk)
Nilotinib(Unsafe)
Pazopanib(Unsafe)
Erlotinib(Unsafe)
Imatinib(Unsafe)
Nilotinib(Unsafe)
Pazopanib(Unsafe)
Erlotinib(Unsafe)
Imatinib(Unsafe)
Dasatinib(Unsafe)
Nilotinib(Unsafe)
Pazopanib(Unsafe)
Erlotinib(Unsafe)
Imatinib(Unsafe)
Dasatinib(Unsafe)
Nilotinib(Unsafe)
Pazopanib(Unsafe)
Erlotinib(Unsafe)
Imatinib(Unsafe)
Dasatinib(Unsafe)
Disclaimer: Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. We do not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.