Is GDC-0449 Safe in Breastfeeding
Question
I am a breastfeeding mother and i want to know if it is safe to use GDC-0449? Is GDC-0449 safe for nursing mother and child? Does GDC-0449 extracts into breast milk? Does GDC-0449 has any long term or short term side effects on infants? Can GDC-0449 influence milk supply or can GDC-0449 decrease milk supply in lactating mothers?
Answer by DrLact: About GDC-0449 usage in lactation
No information is available on the clinical use of GDC-0449 during breastfeeding. Because GDC-0449 is more than 99% bound to plasma proteins, the amount in milk is likely to be low. However, its half-life is 4 days and it might accumulate in the infant. The manufacturer recommends that breastfeeding be discontinued during GDC-0449 therapy and for 24 months after the final dose.
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