Is HSDB 8224 Safe in Breastfeeding

I am a breastfeeding mother and i want to know if it is safe to use HSDB 8224? Is HSDB 8224 safe for nursing mother and child? Does HSDB 8224 extracts into breast milk? Does HSDB 8224 has any long term or short term side effects on infants? Can HSDB 8224 influence milk supply or can HSDB 8224 decrease milk supply in lactating mothers?

A 14-amino acid synthetic peptide related to the endogenous guanylin peptide family.Administered in moderate-severe constipation from irritable bowel syndrome and in idiopathic chronic constipation. It acts locally in the intestine, without being absorbed (EMA 2016). It is metabolized in the intestine obtaining its main active metabolite, des-tyrosine. Both HSDB 8224 and des-tyrosine are digested by intestinal enzymes and transformed into natural amino acids. Since the last update we have not found any published data on its excretion in breast milk. Its pharmacokinetic data (zero or negligible intestinal absorption with undetectable plasma levels and high molecular weight) make it very unlikely that significant amounts will pass to breast milk (EMA 2016).

HSDB 8224 is minimally absorbed from the gastrointestinal tract and the drug and its active metabolite is not measurable in plasma following administration of recommended doses. HSDB 8224 would not be expected to cause any adverse effects in breastfed infants. If HSDB 8224 is required by the mother, it is not a reason to discontinue breastfeeding.