Is HSDB 7656 Safe in Breastfeeding
Question
I am a breastfeeding mother and i want to know if it is safe to use HSDB 7656? Is HSDB 7656 safe for nursing mother and child? Does HSDB 7656 extracts into breast milk? Does HSDB 7656 has any long term or short term side effects on infants? Can HSDB 7656 influence milk supply or can HSDB 7656 decrease milk supply in lactating mothers?
HSDB 7656 lactation summary
- DrLact safety Score for HSDB 7656 is 7 out of 8 which is considered Dangerous as per our analyses.
- A safety Score of 7 indicates that usage of HSDB 7656 may cause toxic or severe side effects in breastfed baby.
- Our study of different scientific research indicates that HSDB 7656 may cause moderate to high side effects or may affect milk supply in lactating mother.
- Our suggestion is to use safer alternate options rather than using HSDB 7656 .
- Usage of HSDB 7656 is in contradiction to breastfeeding hence if it is must to use HSDB 7656 and there is no better alternative available then breastfeeding shall be stopped permanently or temporarily.
- Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.
Answer by Dr. Ru: About HSDB 7656 usage in lactation
Drug is cleared from the body in 25 elimination half-lives. Resuming breastfeeding is possible after 24 hours of pumping-and-dumping.
Answer by DrLact: About HSDB 7656 usage in lactation
Most sources consider breastfeeding to be contraindicated during maternal antineoplastic drug therapy. It might be possible to breastfeed safely during intermittent therapy with an appropriate period of breastfeeding abstinence; the manufacturer recommends an abstinence period of 2 weeks. HSDB 7656 is metabolized to fluorouracil. Limited information indicates that a maternal continuous intravenous fluorouracil infusion at a dose of 200 mg/square meter daily produces undetectable levels in milk. If HSDB 7656 use is undertaken, monitoring of the infant's complete blood count and differential is advisable. Chemotherapy may adversely affect the normal microbiome and chemical makeup of breastmilk.[1] Women who receive chemotherapy during pregnancy are more likely to have difficulty nursing their infant.[2]
Alternate Drugs
Capecitabine(Dangerous)
Thioguanine(Dangerous)
Fluorouracil(Dangerous)
Mercaptopurine(Safe)
Gemcitabine(Dangerous)
Capecitabine(Dangerous)
Fluorouracil(Dangerous)
Methotrexate(Low Risk)