Question

I am a breastfeeding mother and i want to know if it is safe to use C.A.S. 62,602; Diethanolamine fusidate? Is C.A.S. 62,602; Diethanolamine fusidate safe for nursing mother and child? Does C.A.S. 62,602; Diethanolamine fusidate extracts into breast milk? Does C.A.S. 62,602; Diethanolamine fusidate has any long term or short term side effects on infants? Can C.A.S. 62,602; Diethanolamine fusidate influence milk supply or can C.A.S. 62,602; Diethanolamine fusidate decrease milk supply in lactating mothers?

C.A.S. 62,602; Diethanolamine fusidate lactation summary

C.A.S. 62,602; Diethanolamine fusidate is safe in breastfeeding
  • DrLact safety Score for C.A.S. 62,602; Diethanolamine fusidate is 1 out of 8 which is considered Safe as per our analyses.
  • A safety Score of 1 indicates that usage of C.A.S. 62,602; Diethanolamine fusidate is mostly safe during lactation for breastfed baby.
  • Our study of different scientific research also indicates that C.A.S. 62,602; Diethanolamine fusidate does not cause any serious side effects in breastfeeding mothers.
  • Most of scientific studies and research papers declaring usage of C.A.S. 62,602; Diethanolamine fusidate safe in breastfeeding are based on normal dosage and may not hold true for higher dosage.
  • Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.

Answer by Dr. Ru: About C.A.S. 62,602; Diethanolamine fusidate usage in lactation

At latest update no published data on excretion into breast milk were found.Pharmacokinetic data (moderately high molecular weight and high percentage of protein binding capacity) make unlikely the milk passage of significant amounts.Intestinal absorption is also impaired by simultaneous food intake, minimizing any passage toward infant’s plasma. Systemic use is authorized in neonates and infantsCompetes with the ability of bilirubin in binding to albumin, so during the first month of life and especially in premature, the occurrence of neonatal jaundice must be monitored. Take into account possible negative results of bacterial cultures in febrile infants when their mothers are using antibiotics. DERMATOLOGICAL TOPICAL USE:Poor absorption (0.54%) through the skin makes unlikely the passage of significant amount to breast milk.Whenever necessary for treatment of infections in the nipple, apply right after breastfeed and let it to disaapear before the next feeding and if necessary remove excess with a gauze.It should be avoided applying creams, gels and other products for local use on the nipple which could contain paraffin (mineral oil) in order to avoid any swallowing by the infant.

Answer by DrLact: About C.A.S. 62,602; Diethanolamine fusidate usage in lactation

C.A.S. 62,602; Diethanolamine fusidate is not approved for marketing in the United States by the U.S. Food and Drug Administration, but is available in other countries as topical and systemic dosage forms. Data on excretion of C.A.S. 62,602; Diethanolamine fusidate into breastmilk are quite old and not from a well-designed study, but levels in breastmilk after intravenous C.A.S. 62,602; Diethanolamine fusidate appear to be low. With topical products, ensure that the infant's skin does not come into direct contact with the areas of skin that have been treated. Only water-miscible cream or gel products should be applied to the breast because ointments may expose the infant to high levels of mineral paraffins via licking.[1] C.A.S. 62,602; Diethanolamine fusidate applied topically to the nipples appears to be relatively ineffective as a treatment for sore, cracked nipples.

C.A.S. 62,602; Diethanolamine fusidate Possible Effects in Breastfeeding

A small, randomized, unblinded trial of mothers with sore, cracked nipples was performed. C.A.S. 62,602; Diethanolamine fusidate ointment applied to the nipples after each feeding was much less effective (36% vs 79%) than an oral antibiotic (cloxacillin or erythromycin for 10 days) in resolving the problem. Additionally, 43% of patients had no improvement with C.A.S. 62,602; Diethanolamine fusidate compared with 16% with oral antibiotics; 21% worsened with C.A.S. 62,602; Diethanolamine fusidate compared with 5% with oral antibiotics.[3]

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