Question

I am a breastfeeding mother and i want to know if it is safe to use IMC 3G3? Is IMC 3G3 safe for nursing mother and child? Does IMC 3G3 extracts into breast milk? Does IMC 3G3 has any long term or short term side effects on infants? Can IMC 3G3 influence milk supply or can IMC 3G3 decrease milk supply in lactating mothers?

Answer by DrLact: About IMC 3G3 usage in lactation

No information is available on the clinical use of IMC 3G3 during breastfeeding. Because IMC 3G3 is a large protein molecule with a molecular weight of about 154,000 the amount in milk is likely to be very low and absorption is unlikely because it is probably destroyed in the infant's gastrointestinal tract. However, until more data become available, IMC 3G3 should be used with caution during breastfeeding, especially while nursing a newborn or preterm infant. The manufacturer recommends that because of the potential risk for serious adverse reactions in breastfeeding infants from IMC 3G3, women should not breastfeed during treatment with IMC 3G3 and for 3 months following the last dose. IMC 3G3 is a human immunoglobulin G1 (IgG1) antibody. Holder pasteurization (62.5 degrees C for 30 minutes) decreases the concentration of endogenous immunoglobulin G in mature milk by 60 to 79%.[1][2] A study of 67 colostrum samples that underwent Holder pasteurization found that IgG amounts decreased by 34 to 40%. Specific IgG subclasses decreased by different amounts, with IgG1 activity decreasing by about 37%.[3] None of the studies measured IgG activity.
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