Is anti-PDGFR alpha monoclonal antibody IMC-3G3 Safe in Breastfeeding

I am a breastfeeding mother and i want to know if it is safe to use anti-PDGFR alpha monoclonal antibody IMC-3G3? Is anti-PDGFR alpha monoclonal antibody IMC-3G3 safe for nursing mother and child? Does anti-PDGFR alpha monoclonal antibody IMC-3G3 extracts into breast milk? Does anti-PDGFR alpha monoclonal antibody IMC-3G3 has any long term or short term side effects on infants? Can anti-PDGFR alpha monoclonal antibody IMC-3G3 influence milk supply or can anti-PDGFR alpha monoclonal antibody IMC-3G3 decrease milk supply in lactating mothers?

No information is available on the clinical use of anti-PDGFR alpha monoclonal antibody IMC-3G3 during breastfeeding. Because anti-PDGFR alpha monoclonal antibody IMC-3G3 is a large protein molecule with a molecular weight of about 154,000 the amount in milk is likely to be very low and absorption is unlikely because it is probably destroyed in the infant's gastrointestinal tract. However, until more data become available, anti-PDGFR alpha monoclonal antibody IMC-3G3 should be used with caution during breastfeeding, especially while nursing a newborn or preterm infant. The manufacturer recommends that because of the potential risk for serious adverse reactions in breastfeeding infants from anti-PDGFR alpha monoclonal antibody IMC-3G3, women should not breastfeed during treatment with anti-PDGFR alpha monoclonal antibody IMC-3G3 and for 3 months following the last dose. anti-PDGFR alpha monoclonal antibody IMC-3G3 is a human immunoglobulin G1 (IgG1) antibody. Holder pasteurization (62.5 degrees C for 30 minutes) decreases the concentration of endogenous immunoglobulin G in mature milk by 60 to 79%.[1][2] A study of 67 colostrum samples that underwent Holder pasteurization found that IgG amounts decreased by 34 to 40%. Specific IgG subclasses decreased by different amounts, with IgG1 activity decreasing by about 37%.[3] None of the studies measured IgG activity.