Is REGN668 Safe in Breastfeeding
Question
I am a breastfeeding mother and i want to know if it is safe to use REGN668? Is REGN668 safe for nursing mother and child? Does REGN668 extracts into breast milk? Does REGN668 has any long term or short term side effects on infants? Can REGN668 influence milk supply or can REGN668 decrease milk supply in lactating mothers?
Answer by DrLact: About REGN668 usage in lactation
No information is available on the clinical use of REGN668 during breastfeeding. Because REGN668 is a large protein molecule with a molecular weight of about 147,000, the amount in milk is likely to be very low and absorption is unlikely because it is probably destroyed in the infant's gastrointestinal tract. Until more data become available, REGN668 should be used with caution during breastfeeding, especially while nursing a newborn or preterm infant. REGN668 is a human immunoglobulin G4 (IgG4) antibody. Holder pasteurization (62.5 degrees C for 30 minutes) decreases the concentration of endogenous immunoglobulin G by up to 79%.[1][2] A study of 67 colostrum samples that underwent Holder pasteurization found that IgG amounts decreased by 34 to 40%. Specific IgG subclasses decreased by different amounts, with Holder pasteurization having little effect on IgG4 activity.[3] None of the studies measured IgG activity.
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