Question

I am a breastfeeding mother and i want to know if it is safe to use MSB-0010718C? Is MSB-0010718C safe for nursing mother and child? Does MSB-0010718C extracts into breast milk? Does MSB-0010718C has any long term or short term side effects on infants? Can MSB-0010718C influence milk supply or can MSB-0010718C decrease milk supply in lactating mothers?

Answer by DrLact: About MSB-0010718C usage in lactation

No information is available on the clinical use of MSB-0010718C during breastfeeding. Because MSB-0010718C is a large protein molecule with a molecular weight of about 147,000, the amount in milk is likely to be very low and absorption is unlikely because it is probably destroyed in the infant's gastrointestinal tract. Until more data become available, MSB-0010718C should be used with caution during breastfeeding, especially while nursing a newborn or preterm infant. The manufacturer recommends that mothers not breastfeed during treatment and for at least one month after the last dose of MSB-0010718C. MSB-0010718C is a human immunoglobulin G1 (IgG1) lambda antibody. Holder pasteurization (62.5 degrees C for 30 minutes) decreases the concentration of endogenous immunoglobulin G by up to 79%.[1][2] A study of 67 colostrum samples that underwent Holder pasteurization found that IgG amounts decreased by 34 to 40%. Specific IgG subclasses decreased by different amounts, with IgG1 activity decreasing by about 37%.[3] None of the studies measured IgG activity.

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