Is Immunoglobulin G1, anti-(human cd antigen cd274) (human monoclonal MEDI4736 heavy chain), disulfide with human monoclonal MEDI4736 kappa-chain, dimer Safe in Breastfeeding

I am a breastfeeding mother and i want to know if it is safe to use Immunoglobulin G1, anti-(human cd antigen cd274) (human monoclonal MEDI4736 heavy chain), disulfide with human monoclonal MEDI4736 kappa-chain, dimer? Is Immunoglobulin G1, anti-(human cd antigen cd274) (human monoclonal MEDI4736 heavy chain), disulfide with human monoclonal MEDI4736 kappa-chain, dimer safe for nursing mother and child? Does Immunoglobulin G1, anti-(human cd antigen cd274) (human monoclonal MEDI4736 heavy chain), disulfide with human monoclonal MEDI4736 kappa-chain, dimer extracts into breast milk? Does Immunoglobulin G1, anti-(human cd antigen cd274) (human monoclonal MEDI4736 heavy chain), disulfide with human monoclonal MEDI4736 kappa-chain, dimer has any long term or short term side effects on infants? Can Immunoglobulin G1, anti-(human cd antigen cd274) (human monoclonal MEDI4736 heavy chain), disulfide with human monoclonal MEDI4736 kappa-chain, dimer influence milk supply or can Immunoglobulin G1, anti-(human cd antigen cd274) (human monoclonal MEDI4736 heavy chain), disulfide with human monoclonal MEDI4736 kappa-chain, dimer decrease milk supply in lactating mothers?

No information is available on the clinical use of Immunoglobulin G1, anti-(human cd antigen cd274) (human monoclonal MEDI4736 heavy chain), disulfide with human monoclonal MEDI4736 kappa-chain, dimer during breastfeeding. Because Immunoglobulin G1, anti-(human cd antigen cd274) (human monoclonal MEDI4736 heavy chain), disulfide with human monoclonal MEDI4736 kappa-chain, dimer is a large protein molecule with a molecular weight of about 146,000, the amount in milk is likely to be very low and absorption is unlikely because it is probably destroyed in the infant's gastrointestinal tract. Until more data become available, Immunoglobulin G1, anti-(human cd antigen cd274) (human monoclonal MEDI4736 heavy chain), disulfide with human monoclonal MEDI4736 kappa-chain, dimer should be used with caution during breastfeeding, especially while nursing a newborn or preterm infant. The manufacturer recommends that mothers not breastfeed during treatment and for at least 3 months after the last dose of Immunoglobulin G1, anti-(human cd antigen cd274) (human monoclonal MEDI4736 heavy chain), disulfide with human monoclonal MEDI4736 kappa-chain, dimer. Immunoglobulin G1, anti-(human cd antigen cd274) (human monoclonal MEDI4736 heavy chain), disulfide with human monoclonal MEDI4736 kappa-chain, dimer is a human immunoglobulin G1 (IgG1) kappa antibody. Holder pasteurization (62.5 degrees C for 30 minutes) decreases the concentration of endogenous immunoglobulin G by up to 79%.[1][2] A study of 67 colostrum samples that underwent Holder pasteurization found that IgG amounts decreased by 34 to 40%. Specific IgG subclasses decreased by different amounts, with IgG1 activity decreasing by about 37%.[3] None of the studies measured IgG activity.