Question

I am a breastfeeding mother and i want to know if it is safe to use SAR 153191? Is SAR 153191 safe for nursing mother and child? Does SAR 153191 extracts into breast milk? Does SAR 153191 has any long term or short term side effects on infants? Can SAR 153191 influence milk supply or can SAR 153191 decrease milk supply in lactating mothers?

Answer by DrLact: About SAR 153191 usage in lactation

No information is available on the clinical use of SAR 153191 during breastfeeding. Because SAR 153191 is a large protein molecule with a molecular weight of about 150,000, the amount in milk is likely to be very low and absorption is unlikely because it is probably destroyed in the infant's gastrointestinal tract. If SAR 153191 is required by the mother, it is not a reason to discontinue breastfeeding.[1] Until more data become available, SAR 153191 should be used with caution during breastfeeding, especially while nursing a newborn or preterm infant. SAR 153191 is a human immunoglobulin G1 (IgG1) antibody. Holder pasteurization (62.5 degrees C for 30 minutes) decreases the concentration of endogenous immunoglobulin G in mature milk by 60 to 79%.[2][3] A study of 67 colostrum samples that underwent Holder pasteurization found that IgG amounts decreased by 34 to 40%. Specific IgG subclasses decreased by different amounts, with IgG1 activity decreasing by about 37%.[4] None of the studies measured IgG activity.

Synonyms of SAR 153191

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