Is REGN 88 Safe in Breastfeeding

I am a breastfeeding mother and i want to know if it is safe to use REGN 88? Is REGN 88 safe for nursing mother and child? Does REGN 88 extracts into breast milk? Does REGN 88 has any long term or short term side effects on infants? Can REGN 88 influence milk supply or can REGN 88 decrease milk supply in lactating mothers?

No information is available on the clinical use of REGN 88 during breastfeeding. Because REGN 88 is a large protein molecule with a molecular weight of about 150,000, the amount in milk is likely to be very low and absorption is unlikely because it is probably destroyed in the infant's gastrointestinal tract. If REGN 88 is required by the mother, it is not a reason to discontinue breastfeeding.[1] Until more data become available, REGN 88 should be used with caution during breastfeeding, especially while nursing a newborn or preterm infant. REGN 88 is a human immunoglobulin G1 (IgG1) antibody. Holder pasteurization (62.5 degrees C for 30 minutes) decreases the concentration of endogenous immunoglobulin G in mature milk by 60 to 79%.[2][3] A study of 67 colostrum samples that underwent Holder pasteurization found that IgG amounts decreased by 34 to 40%. Specific IgG subclasses decreased by different amounts, with IgG1 activity decreasing by about 37%.[4] None of the studies measured IgG activity.