Question

I am a breastfeeding mother and i want to know if it is safe to use Kevzara? Is Kevzara safe for nursing mother and child? Does Kevzara extracts into breast milk? Does Kevzara has any long term or short term side effects on infants? Can Kevzara influence milk supply or can Kevzara decrease milk supply in lactating mothers?

Answer by DrLact: About Kevzara usage in lactation

No information is available on the clinical use of Kevzara during breastfeeding. Because Kevzara is a large protein molecule with a molecular weight of about 150,000, the amount in milk is likely to be very low and absorption is unlikely because it is probably destroyed in the infant's gastrointestinal tract. If Kevzara is required by the mother, it is not a reason to discontinue breastfeeding.[1] Until more data become available, Kevzara should be used with caution during breastfeeding, especially while nursing a newborn or preterm infant. Kevzara is a human immunoglobulin G1 (IgG1) antibody. Holder pasteurization (62.5 degrees C for 30 minutes) decreases the concentration of endogenous immunoglobulin G in mature milk by 60 to 79%.[2][3] A study of 67 colostrum samples that underwent Holder pasteurization found that IgG amounts decreased by 34 to 40%. Specific IgG subclasses decreased by different amounts, with IgG1 activity decreasing by about 37%.[4] None of the studies measured IgG activity.
Disclaimer: Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. We do not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.