Is AP 26113 Safe in Breastfeeding

Question

I am a breastfeeding mother and i want to know if it is safe to use AP 26113? Is AP 26113 safe for nursing mother and child? Does AP 26113 extracts into breast milk? Does AP 26113 has any long term or short term side effects on infants? Can AP 26113 influence milk supply or can AP 26113 decrease milk supply in lactating mothers?

Answer by DrLact: About AP 26113 usage in lactation

No information is available on the clinical use of AP 26113 during breastfeeding. The manufacturer recommends that breastfeeding be discontinued during AP 26113 therapy and for 1 week after the final dose.

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Synonyms of AP 26113

UNII-HYW8DB273J

AP-26113

2,4-Pyrimidinediamine, 5-chloro-N4-(2-(dimethylphosphinyl)phenyl)-N2-(2-methoxy-4-(4-(4-methyl-1-piperazinyl)-1-piperidinyl)phenyl)-

(2-((5-Chloro-2-((2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)amino)pyrimidin-4-yl)amino)phenyl)dimethyl-,delta5-phosphanone

5-Chloro-N4-(2-(dimethylphosphoryl)phenyl)-N2-(2-methoxy-4-(4-(4-methylpiperazin-1- yl)piperidin-1-yl)phenyl)pyrimidine-2,4-diamine

AP26113

Brigatinib [USAN]

ALUNBRIG

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