Is Tremfya Safe in Breastfeeding

I am a breastfeeding mother and i want to know if it is safe to use Tremfya? Is Tremfya safe for nursing mother and child? Does Tremfya extracts into breast milk? Does Tremfya has any long term or short term side effects on infants? Can Tremfya influence milk supply or can Tremfya decrease milk supply in lactating mothers?

No information is available on the clinical use of Tremfya during breastfeeding. Because Tremfya is a large protein molecule with a molecular weight of , the amount in milk is likely to be very low and absorption is unlikely because it is probably destroyed in the infant's gastrointestinal tract. Until more data become available, Tremfya should be used with caution during breastfeeding, especially while nursing a newborn or preterm infant. Tremfya is a human immunoglobulin G1 (IgG1) lambda antibody. Holder pasteurization (62.5 degrees C for 30 minutes) decreases the concentration of endogenous immunoglobulin G by up to 79%.[1][2] A study of 67 colostrum samples that underwent Holder pasteurization found that IgG amounts decreased by 34 to 40%. Specific IgG subclasses decreased by different amounts, with IgG1 activity decreasing by about 37%.[3] None of the studies measured IgG activity.