Is CMC-544 Safe in Breastfeeding
Question
I am a breastfeeding mother and i want to know if it is safe to use CMC-544? Is CMC-544 safe for nursing mother and child? Does CMC-544 extracts into breast milk? Does CMC-544 has any long term or short term side effects on infants? Can CMC-544 influence milk supply or can CMC-544 decrease milk supply in lactating mothers?
Answer by DrLact: About CMC-544 usage in lactation
No information is available on the clinical use of inotuzumab oxogamicin during breastfeeding. Because inotuzumab oxogamicin is a large protein molecule with a molecular weight of 168,000 and its active metabolite is 97% plasma protein bound, the amount in milk is likely to be very low. However, the half-life of inotuzumab oxogamicin is about 12.3 days and it might accumulate in the infant. Until more data become available, inotuzumab oxogamicin should be used with caution during breastfeeding, especially while nursing a newborn or preterm infant. The manufacturer recommends that breastfeeding be discontinued during inotuzumab oxogamicin therapy for at least 2 months after the last dose.
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